Great Ormond Street Hospital for Children.
An innovative strategy for regenerating skeletal muscle tissue using cells from the recipient's own body is outlined in UCL research published today. The paper, authored by Dr Paulo de Coppi (UCL Institute of Child Health and surgeon at Great Ormond Street Hospital) and colleagues, shows that damaged muscle tissues treated with satellite cells in a special degradable hydrogel showed satisfactory regeneration and muscle activity. Muscle activity in repaired muscle in a mouse model was comparable with untreated muscles. This is the first time muscle function has been proved by physiological tests. The research is published in the Journal of the Federation of American Societies for Experimental Biology and represents an impressive development in the growing field of regenerative medicine. Satellite cells (SCs), freshly isolated or transplanted within their niche, are presently considered the best source for muscle regeneration. They are located around existing muscles.
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