Genetic study uncovers hidden pieces of eye disease puzzle 

Genetic study uncovers hidden pieces of eye disease puzzle  Scientists have taken a significant step forward in their search for the origin of a progressive eye condition which can cause sight loss. A new study into keratoconus by an international team of researchers, including a Leeds group led by Chris Inglehearn, Professor of Molecular Ophthalmology in the School of Medicine , has for the first time detected DNA variations which could provide clues as to how the disease develops. Keratoconus causes the cornea, the clear outer layer at the front of the eye, to thin and bulge outwards into a cone shape over time, resulting in blurred vision and sometimes blindness. It usually emerges in young adulthood, often with lifelong consequences, and affects on average 1 in 375, though in some populations this figure is much higher. It is more common in people with an affected relative, leading scientists to believe there could be a genetic link. This multinational, multicentre study gives us the first real insights into the cause of this potentially blinding condition. Glasses or contact lenses can be used to correct vision in the early stages.