Non-genetic cancer mechanism

The discovery is a major breakthrough because, until now, genetic aberrations have been seen as the main cause of almost all cancer. The research, published today in the journal Oncogene , demonstrates that protein imbalance is a powerful prognostic tool, indicating whether or not patients are likely to respond to chemotherapy and whether a tumour is likely to spread to other sites. The findings also open the possibility of new therapies aimed at measuring and preventing dangerous imbalances in cells. Lead author Professor John Ladbury, Dean of the University of Leeds’ Faculty of Biological Sciences and Professor of Mechanistic Biology, said: “There has been huge investment in sequencing the human genome with the idea that if we get all the relevant genetic information we can predict whether you have a predisposition to cancer and, ultimately, use a precision medicine-based approach to develop a therapeutic approach. Our study demonstrates that genetic screening alone is not enough. The research, led by scientists at the University of Leeds and The University of Texas MD Anderson Cancer Center , focused on the “Akt pathway,” a signalling pathway within cells that drives cancer formation and the spread of cancers through the body. Under normal conditions, the cell receives external signals through a cell wall-bound receptor (FGFR2 in this study).