A gene mutation for excessive alcohol drinking found

A gene mutation for excessive alcohol drinking found. Sussex researchers are among a team of UK scientists who have discovered a gene that regulates alcohol consumption and, when faulty, can cause excessive drinking. They have also identified the mechanism underlying this phenomenon. The study showed that normal mice show no interest in alcohol and drink little or no alcohol when offered a free choice between a bottle of water and a bottle of diluted alcohol. However, mice with a genetic mutation to the gene Gabrb1 overwhelmingly preferred drinking alcohol over water, choosing to consume almost 85% of their daily fluid as drinks containing alcohol. The consortium of researchers from five UK universities - Imperial College London, Newcastle University, University of Sussex, University College London and University of Dundee - and the MRC Mammalian Genetics Unit (MGU) at Harwell, funded by the Medical Research Council (MRC), Wellcome Trust and ERAB, publish their findings today (26 November) in Nature. University of Sussex psychologist Professor Dai Stephens, who leads the Medical Research Council Addiction cross-university team working on how chemical receptors in the brain influence drug abuse, said: "Why some people abuse alcohol while others are readily able to control their drinking is still something of a mystery for science.