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Health - Pharmacology - 10.09.2020
Punctured lung affects almost one in a hundred hospitalised COVID-19 patients
Punctured lung affects almost one in a hundred hospitalised COVID-19 patients
As many as one in 100 patients admitted to hospital with COVID-19 develop a pneumothorax - a 'punctured lung' - according to a study led by Cambridge researchers. Doctors need to be alert to the possibility of a punctured lung in patients with COVID-19, even in people who would not be thought to be typical at-risk patients Stefan Marciniak Like the inner tube of bicycle or car tyre, damage to the lungs can lead to a puncture.

Health - Pharmacology - 10.09.2020
Discovery of four Covid-19 risk groups helps guide treatment
People who are admitted to hospital with Covid-19 can be divided into four distinct groups, according to data from the world's largest study of patients with the disease. Researchers identified the groups using clinical information and tests carried out upon arrival at hospital to predict the patients' risk of death - ranging from low to very high.

Health - Pharmacology - 09.09.2020
Patients set to benefit from new guidelines on Artificial Intelligence health solutions
Patients could benefit from faster and more effective introduction of artificial intelligence (AI) innovations to diagnose and treat disease - thanks to the first international standards for reporting of clinical trials for AI. As evaluation of health interventions involving machine learning or other AI systems moves into clinical trials, an international group has developed guidelines aiming to improve the quality of these studies and ensure that they are reported transparently.

Pharmacology - Health - 07.09.2020
Genetic study of proteins is a breakthrough in drug development for complex diseases
Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. Working in collaboration with pharmaceutical companies, Bristol researchers have developed a comprehensive analysis pipeline using genetic prediction of protein levels to prioritise drug targets, and have quantified the potential of this approach for reducing the failure rate of drug development.

Health - Pharmacology - 05.09.2020
Scientists create blueprint to vaccinate in Bangladesh and beyond
Scientists create blueprint to vaccinate in Bangladesh and beyond
Scientists will work in Bangladesh to create a blueprint to help ensure that medics can get a COVID-19 vaccine to everyone who needs it across the Global South. Universal vaccine access is already a major challenge in low-income countries, due to the lack of robust refrigerated cooling networks especially to remote communities.

Life Sciences - Pharmacology - 04.09.2020
Genetic links to drug and alcohol use among young people
Young people who are genetically predisposed to risk-taking, low extraversion and schizophrenia are more likely to use alcohol, cigarettes, cannabis, or other illicit drugs, according to a new UCL-led study. The researchers say that the findings, published in Addiction Biology , are in line with the notion that people who are more vulnerable to psychopathology or certain personality traits are more inclined to try several types of drugs or use them to 'self-medicate'.

Health - Pharmacology - 03.09.2020
Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV .

Health - Pharmacology - 02.09.2020
Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients
Corticosteroids reduce the risk of death among critically ill COVID-19 patients by 20 per cent, an analysis of seven trials published today [2 September] in the Journal of the American Medical Association (JAMA) has found. The results of three of the trials included in the meta-analysis are also published in JAMA today.

Health - Pharmacology - 02.09.2020
Combining PCR and antibody tests at point of care dramatically increases COVID-19 detection in hospitalised patients
Combining PCR and antibody tests at point of care dramatically increases COVID-19 detection in hospitalised patients
A Cambridge hospital has piloted the use of combined rapid point-of-care nucleic acid and antibody testing for SARS-CoV-2 infection after researchers at the University of Cambridge showed that this approach was superior to virus detection alone for diagnosing COVID-19 disease. PCR and antibody tests both have limitations because of the nature of coronavirus infection and how our body responds.

Health - Pharmacology - 31.08.2020
Implant choice more important than surgeon skill for hip replacement success
Implant choice more important than surgeon skill for hip replacement success
A study analysing over 650,000 hip replacement patients across England and Wales over 14 years sought to investigate why one hospital has consistently been identified as having better than expected outcomes compared to other settings. The findings have shown that the outstanding hip implant survival results seen in one centre in the UK are associated with implant choice more than surgeon skill.

Pharmacology - Health - 25.08.2020
Better drug treatment for miscarriage as patients struggle to access surgery in Covid-19 pandemic
The trial found that the combined drug treatment worked in 83% of cases, compared to 76% in the placebo group - and crucially, it reduced the need for surgery. A new drug combination is more effective for women having miscarriages without symptoms than current standard NHS treatment, according to an NIHR funded study from Tommy's National Centre for Miscarriage Research published today in The Lancet.

Health - Pharmacology - 24.08.2020
Using hydroxychloroquine with common antibiotic increases cardiovascular risk
The combination of hydroxychloroquine and azithromycin has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed comparing hydroxychloroquine treatment to hydroxychloroquine and azithromycin treatment for rheumatoid arthritis patients. Hydroxychloroquine is commonly used to treat rheumatoid arthritis, while azithromycin is a frequently-prescribed antibiotic to treat infections such as pneumonia, chest and sinus infections, etc.

Health - Pharmacology - 24.08.2020
Clinical research reduced by 87 per cent at peak of pandemic
At the peak of the COVID-19 pandemic, clinical research capacity may have been reduced by up to 87% in England, finds a new study led by UCL academics.

Pharmacology - Health - 19.08.2020
Breakthrough research breathes hope into a new treatment for asthma
An international team of scientists, led by the University of Glasgow, has announced findings that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD). The breakthrough findings, published today in Science Translational Medicine , identify a new class of drugs that reverse the symptoms of asthma in animal models.

Pharmacology - 17.08.2020
Targeted treatment for depression could benefit patients with psychosis
Patients with early onset psychosis may benefit from treatment for depression, including with anti-depressants alongside other medication, new research shows. According to scientists at the University of Birmingham's Institute for Mental Health , depression may be an intrinsic part of early phase psychotic disorders that should be treated together with other more prominent symptoms to improve patient outcomes.

Health - Pharmacology - 12.08.2020
Meditation-relaxation therapy may offer escape from the terror of sleep paralysis
Meditation-relaxation therapy may offer escape from the terror of sleep paralysis
Sleep paralysis - a condition thought to explain a number of mysterious experiences including alleged cases of alien abduction and demonic night-time visits - could be treated using a technique of meditation-relaxation, suggests a pilot study published today. I know first-hand how terrifying sleep paralysis can be, having experienced it many times myself.

Pharmacology - 11.08.2020
What patients want most from their GP is trust and respect, finds study
Relationships between GPs and patients are changing. It is becoming more difficult for patients to see their preferred GP. In a study by researchers from the University of Bristol's Centre for Academic Primary Care, patients reported that, regardless of whether they were able to see the same GP or not, what they most wanted is to be trusted and respected by their GP.

Pharmacology - Life Sciences - 07.08.2020
A novel strategy for using compounds as 'anti-evolution' drugs to combat antibiotic resistance
A novel strategy for using compounds as ’anti-evolution’ drugs to combat antibiotic resistance
The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance. Researchers at Oxford University have tested this hypothesis by quantifying differences in evolvability between pathogen strains and by searching for 'potentiator' genes that accelerate the evolution of resistance.

Health - Pharmacology - 04.08.2020
Immunotherapy biomarker discovery could benefit thousands with Type 1 diabetes
Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively. Type 1 diabetes is an autoimmune disease, which means it is caused by the body's own immune system attacking healthy body tissues.

Health - Pharmacology - 30.07.2020
'Pill on a string' test to transform oesophageal cancer diagnosis
’Pill on a string’ test to transform oesophageal cancer diagnosis
A 'pill on a string' test can identify ten times more people with Barrett's oesophagus than the usual GP route, after results from a 3-year trial were published in the medical journalá The Lancet . It's taken almost a decade of research and testing thousands of patients to show that we've developed a better route to diagnosing Barrett's oesophagus Rebecca Fitzgerald The test, which can be carried out by a nurse in a GP surgery, is also better at picking up abnormal cells and potentially early-stage cancer.
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