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Health - Pharmacology - 04.03.2021
Rapid point-of-care test for respiratory infections liked by GPs and may reduce antibiotic prescribing
Rapid point-of-care test for respiratory infections liked by GPs and may reduce antibiotic prescribing
A rapid microbiological point-of-care test to diagnose respiratory infections has proved popular with GPs and could reduce antibiotic prescribing in primary care, according to a National Institute for Health Research funded study by researchers at the Centre for Academic Primary Care, University of Bristol.

Health - Pharmacology - 03.03.2021
One dose of COVID-19 vaccines effective against hospitalisations in over 80s
Interim results presented here show the effectiveness of one dose of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines in preventing hospitalisation of people in their 80s with multiple comorbidities. The AvonCAP study results are reported for the first time today [3 March] by researchers from the University of Bristol, University Hospitals Bristol and Weston NHS Foundation Trust (UHBW) and North Bristol NHS Trust (NBT).

Health - Pharmacology - 03.03.2021
OCTAVE to study vaccine responses in patients with impaired immune systems
A new UK study will seek to understand the immune response to COVID-19 vaccinations in patients with certain immunosuppressed conditions, including cancer. The OCTAVE trial, which is funded by the Medical Research Council (MRC), is a collaborative research project involving groups in the Universities of Glasgow, Birmingham, Oxford, Liverpool, Imperial College London and Leeds Teaching Hospitals NHS Trust.

Health - Pharmacology - 03.03.2021
New study launches into COVID-19 vaccine responses in patients with impaired immune systems
New study launches into COVID-19 vaccine responses in patients with impaired immune systems
A new UK study sponsored and run by the University of Birmingham has launched aiming to better understand the immune response to COVID-19 vaccinations in patients with certain immunosuppressed conditions including cancer. The OCTAVE trial, which is funded by the Medical Research Council (MRC), is a collaborative research project involving the Universities of Birmingham, Glasgow, Oxford, Liverpool, Imperial College London and Leeds Teaching Hospitals NHS Trust.

Health - Pharmacology - 26.02.2021
Single dose of vaccine acts as 'booster' in those with prior COVID-19 infection
Single dose of vaccine acts as ’booster’ in those with prior COVID-19 infection
People who have previously had COVID-19 have an enhanced antibody response with a single dose of RNA vaccine, finds new research co-led by UCL researchers. These are the findings of a study, published as a research letter* in the Lancet , of 51 UK healthcare workers, around half of whom had a previous laboratory-confirmed SARS-CoV-2 infection.

Health - Pharmacology - 26.02.2021
Embed Germ Defence behaviours at home to reduce virus spread now and in the future
As COVID-19 vaccines are rolled out, a roadmap for unlocking Britain is announced, new research which looked at data from over 28,000 users of the website 'Germ Defence' since May 2020 highlights the continued, critical importance of breaking chains of virus transmission within our homes.

Health - Pharmacology - 25.02.2021
Opioid agonist treatment could substantially reduce drug related deaths if used more widely
New evidence that opioid agonists such as methadone and buprenorphine could substantially reduce drug related deaths if more widely used in the community and prison, and for longer, has been published in Lancet Psychiatry today [25 February]. Treatment of people addicted to opioids with methadone or buprenorphine also known as 'opioid agonist treatment' (OAT) reduces many of the harms associated with injecting drug use including death by overdose, suicide, injury, or other causes.

Health - Pharmacology - 24.02.2021
Some men with testicular cancer may benefit from fewer CT scans
Patients who have had treatment for early-stage testicular cancer could benefit from fewer monitoring scans, reducing the harmful radiation they are exposed to from computerized tomography (CT) imaging, according to the results of a new clinical trial involving UCL researchers. Funded by Cancer Research UK and led by researchers at UCL, The Institute of Cancer Research, London, and Leeds/Huddersfield, the study found that using magnetic resonance imaging (MRI) instead of CT scans was as effective at picking up signs of cancer relapse.

Health - Pharmacology - 23.02.2021
Scientists launch a pre-emptive strike on deadly post-transplant infection
Scientists launch a pre-emptive strike on deadly post-transplant infection
A potential new treatment to protect  immunosuppressed  patients from human  cytomegalovirus  ( HCMV ) has been discovered by scientists at the University of Cambridge. Their study shows that certain epigenetic inhibitors expose and help to destroy dormant  HCMV  infections, which often reactivate to cause serious illness and death in these vulnerable groups.

Health - Pharmacology - 22.02.2021
Vaccine roll-out working, first national study
Vaccine roll-out working, first national study
Vaccination has been linked to a substantial reduction in the risk of Covid-19 admissions to Scotland's hospitals, landmark research suggests. The study is the first to describe across an entire country the effect of the Pfizer and Oxford-AstraZeneca jabs in the community on preventing severe illness resulting in hospitalisation.

Health - Pharmacology - 18.02.2021
Heart damage in half of COVID-19 patients with raised protein levels
More than 50% of patients hospitalised with COVID-19, who had raised levels of a protein called troponin, have some heart damage, finds a new magnetic resonance imaging study, led by UCL scientists. More than 50% of patients hospitalised with COVID-19, who had raised levels of a protein called troponin, have some myocardial injury (heart damage), finds a new magnetic resonance imaging study, led by UCL scientists.

Health - Pharmacology - 16.02.2021
Higher Covid-19 risk for middle-aged people with type 2 diabetes
A large-scale analysis involving UCL and funded by Diabetes UK has found a disproportionately higher Covid-19 death risk in middle-aged people with type 2 diabetes, raising questions over vaccination strategies across Europe. The study, published in the journal Diabetologia , found that compared to people of a similar age without type 2 diabetes, the additional COVID-19 mortality risk from having type 2 diabetes increases the younger someone is.

Health - Pharmacology - 16.02.2021
Oxford-led technology to help those at high risk from COVID-19
Oxford-led technology to help those at high risk from COVID-19
Research led by Professor Julia Hippisley-Cox in the University of Oxford's Nuffield Department of Primary Care Health Sciences, with collaborators across the UK, found that there are several health and personal factors which, when combined, could mean someone is at a higher risk from COVID-19. These include characteristics like age, ethnicity and BMI, as well as certain medical conditions and treatments.

Health - Pharmacology - 11.02.2021
Tocilizumab reduces deaths in patients hospitalised with COVID-19
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) has demonstrated that an anti-inflammatory treatment, tocilizumab, reduces the risk of death when given to hospitalised patients with severe COVID-19. The study also showed that tocilizumab shortens the time until patients are successfully discharged from hospital and reduces the need for a mechanical ventilator.

Health - Pharmacology - 09.02.2021
Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests | University of Oxford
Early treatment with a medication commonly used to treat asthma appears to significantly reduce the need for urgent care and hospitalisation in people with COVID-19, researchers at the have found. The STOIC study found that inhaled budesonide given to patients with COVID-19 within seven days of the onset of symptoms also reduced recovery time.

Health - Pharmacology - 09.02.2021
COVID R&D response shows what’s possible for future healthcare and environmental innovation
New analysis of the R&D response to COVID argues that future innovation could be dramatically scaled up to tackle other major diseases or even climate change. Last updated on Tuesday 9 February 2021 Policymakers need to rethink their approach to tackling long-standing healthcare and environmental challenges and can learn lessons from the success of research and development in responding to COVID-19, say the authors of a new study.

Health - Pharmacology - 08.02.2021
Respiratory support used for COVID-19 patients produce less aerosol emission than breathing, speaking or coughing
Respiratory support used to treat patients with severe COVID-19 are associated with less aerosol emission than breathing, speaking or coughing new research suggests. The study led by researchers from the University of Bristol and North Bristol NHS Trust (NBT) is published on the pre-print server medRxiv.

Pharmacology - Health - 08.02.2021
Clinical trials begin to investigate treatment for diabetic eye disease
A new approach to treating one of the leading causes of blindness among patients with diabetes is being tested in clinical trials which begin this month. The trial involves 48 patient volunteers with diabetic macular oedema (DMO), a disease where blood vessels leak fluid into the retina. It is the most common cause of vision loss among people with diabetic retinopathy, affecting approximately 21 million people worldwide.

Health - Pharmacology - 05.02.2021
Severely frail individuals with COVID-19 are three times more likely to die
Severely frail individuals with COVID-19 are three times more likely to die
New research led by the University of Birmingham has revealed for the first time the extent to which frailty increases the risk of mortality in COVID-19 patients. The clinical observational study , involving 5,711 patients with COVID-19 at 55 hospitals across 12 countries, found that very severely frail individuals with COVID-19 are three times more likely to die than those who were not frail, even taking into account their age.

Health - Pharmacology - 02.02.2021
Latest review shows intensive care mortality from COVID-19 continued to fall in 2020, but improvement is slowing
A meta-analysis of global studies has shown that intensive care morality from COVID-19 has continued to fall since the start of the pandemic, but the improvement is slowing and may have plateaued. The study, published today [2 February] in Anaesthesia (a journal of the Association of Anaesthetists), is by Professor Tim Cook, Consultant in Anaesthesia and Intensive Care Medicine at the Royal United Hospitals Bath NHS Foundation Trust and Honorary Professor in Bristol Medical School: Translational Health Sciences (THS) at the University of Bristol, and colleagues.
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