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Life Sciences - Pharmacology - 24.01.2020
Researchers obtain ’high-definition’ view of diabetes-related proteins
Scientists have examined a key receptor for the first time at high resolution - broadening understanding of how it might function, and opening the door to future improvements in treating conditions such as type 2 diabetes - a significant global health problem. Glucagon-like peptide-1 receptors (GLP1R) are found on insulin-producing beta cells of the pancreas and neurons in the brain.

Pharmacology - Health - 24.01.2020
Drug used widely to treat eye condition has ’no benefit’
Researchers from the University of Bristol and University Hospital Southampton have found that a drug used widely to treat a common eye condition has 'no benefit' and should no longer be used. Eplerenone, which is primarily used to treat heart failure, is currently offered widely by ophthalmologists as a treatment for central serous chorioretinopathy (CSCR) based on limited clinical data.

Health - Pharmacology - 23.01.2020
Reveals stark inconsistencies in official UK guidance on Lyme disease
Reveals stark inconsistencies in official UK guidance on Lyme disease
Research reveals stark inconsistencies in official UK guidance on Lyme disease Official guidance on the diagnosis and testing of Lyme disease contains worrying inconsistencies, according to a new research paper. Professor Alex Faulkner at the University of Sussex, and national patient organisation Lyme Research UK have revealed stark discrepancies between the different policy and clinical practice guidance documents issued by Public Health England and other health bodies.

Health - Pharmacology - 21.01.2020
Immune cell health discovery could optimise cancer therapies
Scientists at UCL have discovered how immune cells, essential for tackling infections and cancers, are able to 'recycle' material within themselves in order to stay healthy and function, a breakthrough finding which could lead to more effective immunotherapies. In the study, published in Cell Reports , researchers investigated how 'autophagy' - the natural physiological process of 'self-eating' which allows intracellular components, such as mitochondria, to be degraded and replaced - takes place in liver-based T cells.

Health - Pharmacology - 20.01.2020
Could reduce the risk of sudden cardiac death
New research has shown that by changing the time course of voltage change early when the heart cell contracts it is possible to both withhold a potentially lethal electrical disturbance and improve the strength of cardiac contraction in heart failure at the same time. The research led by the University of Bristol and funded by the Medical Research Council (MRC) is published today [20 January] in the Proceedings of the National Academy of Sciences (PNAS).

Health - Pharmacology - 20.01.2020
Discovery of new T-cell raises prospect of 'universal' cancer therapy
Discovery of new T-cell raises prospect of ’universal’ cancer therapy
Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy. T-cell therapies for cancer - where immune cells are removed, modified and returned to the patient's blood to seek and destroy cancer cells - are the latest paradigm in cancer treatments.

Health - Pharmacology - 20.01.2020
Blood test for eight gene signatures could predict onset of tuberculosis
Scientists at UCL have shown a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless lives. In the study, published in  The Lancet Respiratory Medicine , researchers sought to identify which, if any, gene expression signatures in blood could be used to predict the disease at a very early stage and before symptoms arise.

Pharmacology - Health - 20.01.2020
Prolonged breath-holding could help radiotherapy treatment of cardiac arrhythmias
A technique that enables patients suffering from heart conditions to hold their breath safely for over 5 minutes could have potential as part of a new treatment for cardiac arrhythmias, say researchers at the University of Birmingham. In a new study, published in Frontiers in Physiology, researchers initially proposed the technique as a new means for earlier diagnosis of ischaemic heart disease.

Pharmacology - Social Sciences - 20.01.2020
Racial disparities in drug prescriptions for dementia
Disparities in drug prescribing suggest that black and Asian people with dementia are not receiving the same quality of care as their white peers, according to a new UCL-led study in the UK. Asian people with dementia are less likely to receive anti-dementia drugs, and take them for shorter periods, according to the findings published in Clinical Epidemiology .

Pharmacology - Health - 16.01.2020
Cheap roundworm drug found to enhance the effects of chemotherapy in prostate cancer
Scientists at the University of Glasgow and Cancer Research UK Beatson Institute have tested close to 1000 existing medicines and discovered that a cheap drug commonly used to treat parasitic worm infection could be a game-changing treatment for prostate cancer. Prostate cancer is the most common cancer affecting men and the second most common cause of cancer death for men in the UK.

Pharmacology - Health - 16.01.2020
Patients needed for irritable bowel syndrome trial
Patients needed for irritable bowel syndrome trial
Patients in GP surgeries in Bristol are being invited to take part in a large trial of low-dose amitriptyline for irritable bowel syndrome (IBS) lead by researchers from the universities of Bristol, Leeds and Southampton. IBS is a common gut disorder affecting one in ten people. Abdominal pain, bloating, and altered bowel habit affect patients' quality of life substantially and can force them to take days off work.

Pharmacology - Life Sciences - 16.01.2020
Probiotic drink could offer new way to combat antibiotic resistance
A probiotic drink could become a promising new weapon in the battle against antibiotic resistant bacteria, after a team of scientists at the University of Birmingham engineered and patented a key genetic element that can tackle the genetic basis of resistance. The team is now seeking funding for a clinical trial for the drink which has potential to work against many resistant bacteria commonly found in the human gut including E. coli, Salmonella and Klebsiella pneumoniae.

Pharmacology - Health - 15.01.2020
Stepping up to the challenge: studying drug dosage during an Ebola outbreak
A specialist technique used to study drugs has been completed for the first time during an outbreak of Ebola virus disease. The study published today in eBiomedicine was a collaboration of researchers from Sierra Leone and the University's of Glasgow, Oxford, Cambridge and the Liverpool School of Tropical Medicine.

Health - Pharmacology - 14.01.2020
Routine HIV screening in general practice boosts testing and early diagnosis
Offering HIV screening to new patients in general practice on a routine basis increases testing rates and improves detection and earlier diagnosis, according to research co-led by UCL and Queen Mary University of London HIV testing rates in general practice are low, despite testing being recommended in UK and international guidelines.

Pharmacology - Health - 07.01.2020
Brain tumour research could help future precision medicine
New research on brain tumours could improve patient diagnosis and treatment options as part of a precision medicine approach. Brain tumours are the leading cause of cancer deaths in children and adults under the age of 40, with 16,000* people in the UK diagnosed with a brain tumour each year. The study led by the Brain Tumour Research Centre at the University of Bristol in collaboration with the Cancer Research and Cell Biology (CCRCB) at Queen's University Belfast investigated the genetics of brain tumours.

Health - Pharmacology - 07.01.2020
Marathon running makes arteries younger and lowers blood pressure
Marathon running makes arteries younger and lowers blood pressure
The new year means it's time to set resolutions for 2020, and new research led by UCL and Barts Health NHS Trust suggests running a marathon for the first time could have several health benefits. The study, published by the Journal of the American College of Cardiology, found that for first-time marathon runners, training and completion of the marathon resulted in reductions in blood pressure and aortic stiffening in healthy participants that were equivalent to a four-year reduction in vascular age.

Health - Pharmacology - 02.01.2020
Finds new non-invasive technique to assess brain tumours in children and make treatment less toxic
Ground-breaking research by the University of Birmingham has discovered a new technique to assess the aggressiveness of childhood brain tumours. Funded by Children with Cancer UK, Action Medical Research and The Brain Tumour Charity, the study is the first of its kind and will allow clinicians to give more personalised treatments for childhood brain cancers, which currently account for one third of all childhood cancer deaths in the UK.

Pharmacology - Environment - 31.12.2019
The ten most popular Imperial news stories of 2019
As the decade comes to an end, we reflect on the stories that spiked your interest and topped the 'most read articles' chart this year. Ranked by page views, here are your favourite stories of 2019: 10. Mystery arthritis-linked knee bone three times more common than 100 years ago Imperial News Is it time to adjust the official number of bones in the human body? In April, researchers found that the small fabella bone, once thought to be a relic of the past, has made a comeback over the last century.

Pharmacology - Health - 19.12.2019
Flu antiviral has bigger benefits for sicker, older patients
A Europe-wide study conducted over three flu seasons finds that the antiviral drug, oseltamivir (Tamiflu ), can help people recover from flu-like illness about one-day sooner on average, with older, sicker patients who have been unwell for longer recovering two-to-three days sooner. Published today in The Lancet , the European Commission-funded 'ALIC4E' study was led by the Universities of Oxford (UK) and Utrecht (The Netherlands).

Health - Pharmacology - 18.12.2019
Could AI help develop personalised psychosis therapies?
A new multicentre study will investigate the link between brain inflammation and psychosis, and use artificial intelligence techniques to identify patients that might benefit most from novel treatments. The study, funded by UKRI Medical Research Council , is led by the Universities of Birmingham and Cambridge.
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