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Pharmacology - Psychology - 27.11.2020
Treatment for drug addiction - how do patients cope in lockdown?
There are encouraging signs that people in treatment for drug addiction can manage their medication when they are entrusted with a substantial quantity of opiate substitutes and told to take it in small daily doses, finds a new 'early insight' report from researchers at the Universities of Bristol and Bath.

Health - Pharmacology - 25.11.2020
New immunotherapy shows promise against rare childhood cancer
A novel CAR T-cell therapy developed by researchers at UCL and designed to target cancerous tumours, has shown promising early results in children with neuroblastoma, a rare form of childhood cancer. For this proof-of-principle study, researchers at the UCL Great Ormond Street Institute for Child Health (GOS ICH) and the UCL Cancer Institute modified the patient's own T-cells (a type of immune cell), equipping them to recognise and kill neuroblastoma tumour cells.

Pharmacology - Health - 25.11.2020
New breakthrough in the treatment of rheumatoid arthritis
People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment that not only suppresses inflammation but also significantly reduces patient reported pain scores. Otilimab is a monoclonal antibody, biologic drug, which targets and suppresses the inflammatory cytokine GM-CSF. In a multicentre, dose-ranging trial, led by Professor Chris Buckley at the Universities of Oxford and Birmingham, and sponsored by the Pharmaceutical company GSK, researchers explored the clinical effects of otilimab to prevent inflammation, tissue damage and pain in people with RA.

Health - Pharmacology - 24.11.2020
Rhythm and bleughs: how changes in our stomach’s rhythms steer us away from disgusting sights
Does the sight of maggots squirming in rotten food make you look away in disgust? The phrase 'makes my stomach turn' takes on a new meaning today as researchers at the University of Cambridge reveal that changes in the rhythm of our stomachs prompt us to look away from disgusting images.

Health - Pharmacology - 17.11.2020
Rapid point-of-care testing during and after COVID-19 - how widely should it be used?
Even before the COVID-19 pandemic, the point-of-care testing industry was investing millions of pounds to develop rapid tests to tell us the cause of respiratory infections. The pandemic has accelerated this process. In an editorial published in the British Journal of General Practice today [17 November], researchers from the University of Bristol's Centre for Academic Primary Care ask if we know enough about these tests to merit their widespread use in primary care.

Health - Pharmacology - 17.11.2020
The Zayed Centre for Research celebrates first anniversary
With a vision to develop new treatments and cures for seriously ill children, the Zayed Centre for Research into Rare Disease in Children, is celebrating its first year of work and achievements. Run jointly by UCL and Great Ormond Street Hospital (GOSH) the purpose-built Zayed Centre for Research (ZCR) brings together pioneering research and clinical care under one roof - a world first for paediatric medicine.

Health - Pharmacology - 16.11.2020
UofG researchers report how novel diabetes drugs work to improve the prognosis for patients with heart failure
Scientists at the University of Glasgow have furthered the understanding of how novel diabetes drugs can improve prognosis for patients with heart failure. The results of the SUGAR-DM-HF trial - published in Circulation and presented to the American Heart Association - showed that the drug empagliflozin, originally a treatment for patients with type 2 diabetes, was able to significantly reduce the size of abnormally large hearts, which helps explain how they reduce the risk of hospitalisation and cardiovascular death in patients with heart failure.

Pharmacology - Health - 13.11.2020
Analysis: Believing in conspiracies goes hand in hand with vaccine hesitancy
Dr Gul Deniz Salali, Lecturer in Evolutionary Anthropology and Medicine at UCL, discusses new research which confirms findings from before the pandemic that vaccine hesitancy often coincides with broader anti-scientific thinking. While developing an effective vaccine  probably won't  bring an immediate end to the pandemic, it's clear that things can't begin to return to normal without one.

Pharmacology - 12.11.2020
Interview: Developing a new immunotherapy to gain control of cancer
Scientists at UCL Cancer Institute have developed an experimental immunotherapy drug, which harnesses the immune system in a new way to kill cancer cells. Here lead researcher, Professor Sergio Quezada, discusses the groundbreaking discovery and its potential. "This is not the cure to cancer. I think that's very important to clarify.

Chemistry - Pharmacology - 12.11.2020
Interactive virtual reality emerges as a new tool for drug design against COVID-19
Interactive virtual reality emerges as a new tool for drug design against COVID-19
Bristol scientists have demonstrated a new virtual reality [VR] technique which should help in developing drugs against the SARS-CoV-2 virus - and enable researchers to share models and collaborate in new ways. The innovative tool, created by University of Bristol researchers, and published in the Journal of Chemical Information and Modeling, will help scientists around the world identify anti-viral drug leads more rapidly.

Health - Pharmacology - 11.11.2020
Insights into ’significant’ avoidable harm in primary care
A national study in England has revealed the extent of incidents of significant avoidable harm in primary care. Thirteen GPs reviewed case notes of more than 90,000 patients in three regions across England over a 12-month period as part of the study. They found the main causes of avoidable harm were diagnostic error (more than 60%), medication incidents (more than 25%) and delayed referrals (nearly 11%), and that 80% of incidents could have been identified sooner or prevented if action had been taken.

Pharmacology - Health - 10.11.2020
Next-generation immunotherapy entering early phase clinical trials
Scientists at UCL have invented a new experimental drug that aims to harness the full power of the immune system, launching a two-pronged response against cancer. The pioneering study in mice has been co-funded by Cancer Research UK. The innovative immunotherapy drug, developed by researchers at UCL Cancer Institute, targets suppressive 'regulatory' immune cells inside a tumour.

Health - Pharmacology - 10.11.2020
Newer medicine to prevent gout attacks is as safe as older treatment
A major new study examining the relative safety of medicines for the treatment of gout will be presented at the American College of Rheumatology Convergence conference and will be published in The Lancet. The FAST Study finds no increased risk of cardiovascular events with febuxostat as compared with allopurinol.

Pharmacology - Life Sciences - 04.11.2020
Scientists uncover new layer of complexity in how our bodies respond to drug treatments
Scientists from the University of Glasgow have played an important role in understanding why some patients respond better to drug treatments than others. The study - and involving the University of Glasgow and a number of international partners - uncovers a new layer of complexity in how the body responds to medical treatments by using the power of data analysis on GPCRs.

Health - Pharmacology - 04.11.2020
Funding for salmon drugs may help lower cost of treating deadly human diseases
The University of Glasgow has received funding to repurpose drugs that are currently used to treat some parasitic diseases in humans - Sleeping Sickness, Chagas Disease and Leishmaniasis - to manage amoebic gill disease in Atlantic salmon. Researchers hope that opening new markets for these drugs in the developed world will also help to drive down their costs in the developing world, where unaffordable healthcare can lead to many unnecessary deaths.

Pharmacology - Health - 03.11.2020
New study into a rare type of cancer in abdomen lining shows possible immunotherapy treatment
A new study from the University of Birmingham has found that 50% of patients with a rare type of cancer that has spread into the lining of their abdomen may be suitable for immunotherapy treatment. Unfortunately for around 1% of bowel cancer patients, their cancer spreads to the lining of their abdomen (peritoneal cavity) - known as colorectal peritoneal metastasis (CPM).

Health - Pharmacology - 28.10.2020
Antiviral drugs trialled in the early stages of COVID-19
Two antiviral drugs are being given to COVID-19 positive adults to establish if they stop the virus replicating, as part of a trial led by UCL scientists. The FLARE trial aims to see if favipiravir and lopinavir/ritonavir, alone or in combination, can inhibit viral replication in early infection - within the first few days of illness.

Pharmacology - Health - 27.10.2020
Common diabetes drugs may help prevent Parkinson’s
Elevated risk of Parkinson's disease among people with type 2 diabetes appears to be reduced by some medications used to treat their diabetes, finds a new study led by UCL researchers. The researchers are testing one of the drugs, called exenatide, as a potential Parkinson's treatment in an upcoming clinical trial, and the new findings, published in Brain , lend support to repurposing diabetes medications for people with Parkinson's.

Pharmacology - Health - 27.10.2020
High blood pressure and its drug treatment unlikely to increase entry of COVID-19 virus into cells
Fears that people with high blood pressure are more at risk from severe Covid-19 because it is easier for the virus to enter their cells and tissues have been laid to rest, thanks to research by an international team of scientists The team led by University of Manchester, and including University of Glasgow researchers, also show that speculation over some blood pressure lowering medications that they increase the risk of Covid-19 infection, is likely to be wrong.

Pharmacology - Health - 23.10.2020
Cardiff University-led study into antibiotic use wins research paper of the year
A study into antibiotic use led by Cardiff University and in collaboration with the University of Oxford and King's College London has won research paper of the year. The study, by researchers from Cardiff University's School of Medicine and Centre for Trials Research, found a simple finger-prick blood test could help to prevent unnecessary prescription of antibiotics in patients with chronic obstructive pulmonary disease (COPD).
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