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Health - Pharmacology - 07.02.2025
Rare diseases linked to much higher Covid-19 risk
Rare diseases linked to much higher Covid-19 risk
An England-wide study of 331 rare diseases in over 58 million people co-led by UCL researchers has identified eight rare diseases that carry significantly increased risks for Covid-19-related mortality in fully vaccinated individuals. In the study, published in Lancet Digital Health , the research team called for better inclusion of rare diseases in public health strategies, including future pandemic planning, vaccination policies, and NHS service provision.

Pharmacology - Life Sciences - 06.02.2025
New research seeks to find new ways to target opioid addiction
An international team of researchers, led by the University of Glasgow, hopes to find new ways to target opioid addiction. Supported by a £5m award from the Wellcome Trust, the ground-breaking new project will use genetic and drug-discovery techniques to try to answer the longstanding question: can we have the pain-relief of opioids without the addiction risk?

Health - Pharmacology - 03.02.2025
Researchers leverage large-scale data to uncover new insights into rare diseases and COVID-19
A study of over 58 million people has identified eight rare diseases that carry significantly increased risks for COVID-19-related mortality in fully vaccinated individuals. This important research calls for better inclusion of rare diseases in public health strategies, including future pandemic planning, vaccination policies, and NHS service provision.

Pharmacology - Health - 03.02.2025
Diabetes drug may have hidden health benefits for older adults
A new and increasingly widely used diabetes medication may have additional health benefits for older adults, according to new research which looked at data from more than 300,000 patients who have taken part in clinical trials. The study, led by the University of Glasgow and published in JAMA, is the largest of its kind to assess the health benefits of diabetes medications in different age groups.

Pharmacology - Health - 21.01.2025
Antibiotics, vaccinations and anti-inflammatory medication linked to reduced risk of dementia
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals. We urgently need new treatments to slow the progress of dementia, if not to prevent it.

Health - Pharmacology - 21.01.2025
New study to look at how people develop resistance to flu
An international researchers will investigate how people develop resistance to the flu in an international £1.76m study backed by the Novo Nordisk Foundation. The new project will combine human challenge and vaccine studies to investigate how our immune response in the respiratory tract respond differently to influenza infection and vaccination, which could ultimately help to improve vaccines and treatments.

Chemistry - Pharmacology - 15.01.2025
Innovative enzyme breakthrough could transform drug and chemical manufacturing
Researchers from the Manchester Institute of Biotechnology and Department of Chemistry at The University of Manchester have described a novel enzyme that could significantly change the way essential chemicals and medicines are made. Published today (15 January 2025) in Nature, t'his breakthrough centres on a process called nucleophilic aromatic substitution (S Ar), a class of transformation that is widely used across the chemical industries including pharmaceuticals and agrochemicals.

Health - Pharmacology - 14.01.2025
Safely reducing the use of antibiotics in hospitals
New research finds that PCT (procalcitonin) blood test does not lower antibiotic treatment duration for hospitalised children . A study led by the University of Liverpool, in collaboration with Cardiff University's Centre of Clinical Trials Research, has found that despite previous promising analysis, a blood test used to diagnose infection and sepsis did not reduce the time children spend on intravenous antibiotics in hospitals.

Agronomy / Food Science - Pharmacology - 09.01.2025
New research from the RVC reveals reasons for antibiotic usage in Indian chicken farming
New research from the Royal Veterinary College (RVC), in collaboration with the West Bengal University of Animal & Fishery Sciences (WBUAFS), explored antibiotic use in chicken farming in eastern India, revealing how poultry companies play a significant role in influencing the way antibiotics are used during food production compared to chicken farmers.

Health - Pharmacology - 08.01.2025
AI could improve the success of IVF treatment
Artificial Intelligence (AI) could help doctors identify follicles that are most likely to lead to the birth of a baby during IVF treatment. During IVF treatment, doctors use ultrasound scans to monitor the size of follicles - small sacs in the ovaries containing eggs - to decide when to give a hormone injection known as the 'trigger' to prepare the eggs for collection and ensure that they are ready to be fertilised with sperm to create embryos.

Health - Pharmacology - 08.01.2025
Research helps predict which melanoma patients are most likely to respond to immunotherapy
Research helps predict which melanoma patients are most likely to respond to immunotherapy
New study is a landmark step towards better personalised medicine for cancer patients. An international team of UK and US scientists has discovered that the activity of macrophages - a type of white blood cell that engulf pathogens and cancer cells - can be used to predict whether or not a melanoma patient will respond to immunotherapy.

Pharmacology - Health - 16.12.2024
Deadly mould strains highly likely to acquire resistance to new drugs
Deadly mould strains highly likely to acquire resistance to new drugs
Scientists have identified strains of one of the world's most dangerous fungal pathogens, already resistant to our most effective antifungal drugs, which are also 5-times more likely to acquire resistance to desperately needed new treatments in development. The study - led by two University of Manchester researchers and published in Nature Communications - significantly advances our understanding of how Aspergillus fumigatus rapidly develops drug resistance.

Pharmacology - Health - 06.12.2024
Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
An MRI-based imaging technique developed at the University of Cambridge predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models. We can image a tumour pre-treatment to predict how likely it is to respond, and then we can image again immediately after treatment to confirm whether it has indeed responded Kevin Brindle The technique, called hyperpolarised carbon-13 imaging, can increase the detected signal in an MRI scanner by more than 10,000 times.

Health - Pharmacology - 06.12.2024
Urine test for early detection of lung cancer
Cambridge scientists have developed a urine test for early detection of lung cancer. The test, the first of its kind, detects 'zombie' cells that could indicate the first signs of the disease. Researchers hope that early detection, through the simple urine test, could enable earlier treatment interventions, significantly improving patient outcomes and prognosis.

Health - Pharmacology - 29.11.2024
Global review charts lethal impact of fungal infection after lung disease
Around 32% of people who have had prior damage from lung diseases will die after five years if they also get a common fungal infection, a major global review has found. The review also finds that 15% of people with chronic pulmonary aspergillosis (CPA) die in the first year following other lung diseases.

Health - Pharmacology - 29.11.2024
Scientists expose cells driving aggressive tumour growth
The first computer algorithm capable of identifying which tumour cells are driving aggressive cancer growth has been developed by Cancer Research scientists from UCL and The Francis Crick Institute. The innovative algorithm, called SPRINTER*, analyses individual cells within a tumour to identify those that are growing the most rapidly.

Pharmacology - Health - 06.11.2024
Stronger and higher dose opioids linked to greater all-cause mortality risk
Stronger and higher dose opioids linked to greater all-cause mortality risk
A new international study spanning the United Kingdom, United States, and Canada has revealed important insights into the risks associated with prescribed opioid use for noncancer pain. The research, led by researchers at The University of Manchester and McGill University in Canada which analysed over 1 million patients newly initiated on opioids, found prescription of strong opioids was associated with higher risk of all-cause mortality compared to taking codeine.

Pharmacology - Health - 05.11.2024
Enzyme engineering has the potential to drive green, more efficient drug manufacturing
Enzyme engineering has the potential to drive green, more efficient drug manufacturing
Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for essential drugs, making the process quicker, more efficient, and environmentally friendly. Biocatalysis is a process that uses enzymes as natural catalysts to carry out chemical reactions.

Pharmacology - Chemistry - 04.11.2024
New drug could help fight against treatment-resistant malaria
New drug could help fight against treatment-resistant malaria
An international team of researchers have developed a promising new drug which could help combat the spread of treatment-resistant malaria. The breakthrough development is the first to adapt an approach from cancer treatments to tackle malaria. It works by permanently disabling a protein that Plasmodium falciparum , one of the mosquito-borne parasites which spreads malaria, uses to duplicate itself inside the human body.

Pharmacology - Health - 25.10.2024
Stroke patients could benefit from earlier blood thinning treatment
People with atrial fibrillation (AF) who have a stroke could benefit from blood thinning treatments, known as anticoagulants, at an earlier stage than is currently recommended, finds a new study led by UCL researchers. Results from the British Heart Foundation funded OPTIMAS study are published in the Lancet and presented at the World Stroke Congress 2024.
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