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Pharmacology
Results 151 - 200 of 583.
Low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems
Study shows low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems The first data from the ongoing OCTAVE study show that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions mount a low or undetectable immune response after two doses of the same COVID-19 vaccine.
Study shows low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems The first data from the ongoing OCTAVE study show that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions mount a low or undetectable immune response after two doses of the same COVID-19 vaccine.
Interview: Prof Francois Balloux - ’The pandemic has created a market for gloom and doom’
Francois Balloux (UCL Genetics Institute) discusses the risk of new variants, psychosomatic long Covid and when he expects the crisis to end.
Francois Balloux (UCL Genetics Institute) discusses the risk of new variants, psychosomatic long Covid and when he expects the crisis to end.
Licensed drug could reduce SARS-CoV-2 infection by up to 70 per cent, reveals study
A licensed drug normally used to treat abnormal levels of fatty substances in the blood could reduce infection caused by the SARS-CoV-2 virus by up to 70 per cent, reveals a study in the laboratory by an international collaboration of researchers. The research team, led by the University of Birmingham and Keele University in the UK and the San Raffaele Scientific Institute in Italy, has demonstrated that fenofibrate and its active form (fenofibric acid) can significantly reduce SARS-COV-2 infection in human cells in the laboratory.
A licensed drug normally used to treat abnormal levels of fatty substances in the blood could reduce infection caused by the SARS-CoV-2 virus by up to 70 per cent, reveals a study in the laboratory by an international collaboration of researchers. The research team, led by the University of Birmingham and Keele University in the UK and the San Raffaele Scientific Institute in Italy, has demonstrated that fenofibrate and its active form (fenofibric acid) can significantly reduce SARS-COV-2 infection in human cells in the laboratory.
Medicines Discovery Catapult relaunches Wolfson Radiochemistry facility in Manchester
Medicines Discovery Catapult (MDC) today announces the relaunch of radiochemistry at the Wolfson Molecular Imaging Centre (WMIC) in Manchester.
Medicines Discovery Catapult (MDC) today announces the relaunch of radiochemistry at the Wolfson Molecular Imaging Centre (WMIC) in Manchester.
Lab-grown beating heart cells identify potential drug to prevent COVID-19-related heart damage
Cambridge scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a study published in , they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells. Using stem cells, we've managed to create a model which, in many ways, behaves just like a heart does, beating in rhythm.
Cambridge scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a study published in , they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells. Using stem cells, we've managed to create a model which, in many ways, behaves just like a heart does, beating in rhythm.
RECOVERY-RS trial finds continuous positive airway pressure (CPAP) reduces need for invasive ventilation in hospitalised COVID-19 patients
Landmark UK trial compared three commonly used respiratory interventions to establish which works best for COVID-19 patients with acute respiratory failure.
Landmark UK trial compared three commonly used respiratory interventions to establish which works best for COVID-19 patients with acute respiratory failure.
Artificial pancreas trialled for outpatients with type 2 diabetes for first time
An artificial pancreas could soon help those people living with type 2 diabetes who also require kidney dialysis.
An artificial pancreas could soon help those people living with type 2 diabetes who also require kidney dialysis.
World-first UK trial to assess whether cannabis-based drug could extend life for thousands with aggressive brain tumours
The University of Birmingham will co-ordinate a major UK trial to analyse the efficacy of cannabis-based drug Sativex in treating the most aggressive form of brain tumours.
The University of Birmingham will co-ordinate a major UK trial to analyse the efficacy of cannabis-based drug Sativex in treating the most aggressive form of brain tumours.
Patients who miss multiple GP appointments stay missing from healthcare
Research tracking people across the health service shows that patients who miss multiple GP appointments are not seeking help from Emergency Departments.
Research tracking people across the health service shows that patients who miss multiple GP appointments are not seeking help from Emergency Departments.
New data show rise in hospital admissions for unvaccinated pregnant women
The Chief Midwifery Officer for England will urge expectant mums to have their COVID-19 vaccination as soon as possible.
The Chief Midwifery Officer for England will urge expectant mums to have their COVID-19 vaccination as soon as possible.
Expansion of MR and CT imaging at Salford Royal
Three new, state of the art MRI (Magnetic Resonance Imaging) scanners and a new CT (Computed Tomography) scanner have been installed at Salford Royal, part of the Northern Care Alliance NHS Group (NCA).
Three new, state of the art MRI (Magnetic Resonance Imaging) scanners and a new CT (Computed Tomography) scanner have been installed at Salford Royal, part of the Northern Care Alliance NHS Group (NCA).
Opinion: We cannot escape the threat of Covid-19 until we vaccinate the world
G7 countries are guilty of both hoarding Covid-19 vaccines and blocking others from producing them at scale, says Professor Anthony Costello (UCL Institute for Global Health).
G7 countries are guilty of both hoarding Covid-19 vaccines and blocking others from producing them at scale, says Professor Anthony Costello (UCL Institute for Global Health).
UCLH begins clinical trial of Alzheimer’s drug developed at UCL
A clinical trial of a new drug candidate for Alzheimer's disease which has been developed at UCL in partnership with the pharmaceutical company Eisai has begun at UCLH with participants now being screened. Participants in the trial, conducted at the UCLH Leonard Wolfson Experimental Neurology Centre (NIHR UCLH Clinical Research Facility), will have the rare inherited form of Alzheimer's disease.
A clinical trial of a new drug candidate for Alzheimer's disease which has been developed at UCL in partnership with the pharmaceutical company Eisai has begun at UCLH with participants now being screened. Participants in the trial, conducted at the UCLH Leonard Wolfson Experimental Neurology Centre (NIHR UCLH Clinical Research Facility), will have the rare inherited form of Alzheimer's disease.
Vaccine antibody levels start to wane at around 2-3 months
Total antibody levels appear to start declining from as early as six weeks after complete vaccination and can reduce by more than 50% over 10 weeks, according to new data from UCL's Virus Watch study.
Total antibody levels appear to start declining from as early as six weeks after complete vaccination and can reduce by more than 50% over 10 weeks, according to new data from UCL's Virus Watch study.
Study launched to investigate diet treatment for long COVID
Researchers from the University of Glasgow have been awarded £1 million from the National Institute for Health Research (NIHR) to investigate weight loss treatment for long COVID.
Researchers from the University of Glasgow have been awarded £1 million from the National Institute for Health Research (NIHR) to investigate weight loss treatment for long COVID.
New research studies to help diagnose and treat Long COVID funded by NIHR
Three projects at Oxford have received funding from NIHR to assess breathlessness in Long COVID patients, investigate the impact of Long COVID on families, and examine the role of vaccines in Long COVID.
Three projects at Oxford have received funding from NIHR to assess breathlessness in Long COVID patients, investigate the impact of Long COVID on families, and examine the role of vaccines in Long COVID.
New Zealand drug agency provides model to help insulate NICE from impacts of post-Brexit trade deals
An investigation by CASP researchers suggests safeguards put in place in New Zealand to protect drug policy offer important lessons for UK trade deals.
An investigation by CASP researchers suggests safeguards put in place in New Zealand to protect drug policy offer important lessons for UK trade deals.
Opinion: If Covid-19 is a seasonal virus, why is it spreading during the summer?
Understanding seasonality can help us to work out when the pandemic is likely to be over, says Professor Francois Balloux (UCL Genetics Institute).
Understanding seasonality can help us to work out when the pandemic is likely to be over, says Professor Francois Balloux (UCL Genetics Institute).
Partnership will create the next generation of researchers to transform global healthcare
The Universities of Birmingham, Leicester and Nottingham have joined forces to launch a partnership that will train the next generation of leading researchers the skills required to transform our understanding and treatment of disease.
The Universities of Birmingham, Leicester and Nottingham have joined forces to launch a partnership that will train the next generation of leading researchers the skills required to transform our understanding and treatment of disease.
Opinion: Boris Johnson gave two reasons for lifting all restrictions. Both are wrong
Allowing mass infections now is a terrible idea, even with so many vaccinated. The NHS will struggle to cope, says Professor Christina Pagel (UCL Mathematics).
Allowing mass infections now is a terrible idea, even with so many vaccinated. The NHS will struggle to cope, says Professor Christina Pagel (UCL Mathematics).
COVID:19: Scientists condemn government’s ’dangerous & unethical COVID-19 experiment’
University of Birmingham scientists are among more than 100 experts who have signed a letter published in The Lancet accusing the UK government of conducting a 'dangerous and unethical experiment' and urging it to reconsider its plans to abandon all COVID-19 restrictions.
University of Birmingham scientists are among more than 100 experts who have signed a letter published in The Lancet accusing the UK government of conducting a 'dangerous and unethical experiment' and urging it to reconsider its plans to abandon all COVID-19 restrictions.
Brain cancer trial recruits largest ever number of patients
A UCL-led clinical trial for patients with brain cancer has recruited more UK participants than ever before for a study of its kind.
A UCL-led clinical trial for patients with brain cancer has recruited more UK participants than ever before for a study of its kind.
UofG researchers to play a key role in major EU arthritis research project
Researchers at the University of Glasgow will play a key role in the major new EU research project, HIPPOCRATES, which will promote the early identification of and improve outcomes for patients with psoriatic arthritis.
Researchers at the University of Glasgow will play a key role in the major new EU research project, HIPPOCRATES, which will promote the early identification of and improve outcomes for patients with psoriatic arthritis.
Analysis: Could expanding the Covid-19 case definition improve the UK’s pandemic response’
PhD candidate Alex Crozier (UCL Biosciences) and colleagues write in the BMJ about the potential opportunities and challenges of expanding the symptom list linked to self-isolation and testing as vaccines are rolled out.
PhD candidate Alex Crozier (UCL Biosciences) and colleagues write in the BMJ about the potential opportunities and challenges of expanding the symptom list linked to self-isolation and testing as vaccines are rolled out.
World-leading study begins into robotic surgery for knee replacement with major £1.6 million funding grant
New clinical trial led by University of Warwick and University Hospitals of Coventry and Warwickshire A major national study will pitch human skill against machine precision as it compares the benefits of knee replacement surgery performed using a robot to a surgeon using traditional methods.
New clinical trial led by University of Warwick and University Hospitals of Coventry and Warwickshire A major national study will pitch human skill against machine precision as it compares the benefits of knee replacement surgery performed using a robot to a surgeon using traditional methods.
Blood cancer trial sponsored by the University of Birmingham opens for recruitment
A new Cancer Research UK-funded clinical trial being sponsored by the University of Birmingham has opened for recruitment aiming to investigate the efficacy of a novel treatment for patients affected by a specific type of blood cancer.
A new Cancer Research UK-funded clinical trial being sponsored by the University of Birmingham has opened for recruitment aiming to investigate the efficacy of a novel treatment for patients affected by a specific type of blood cancer.
Gene editing therapy paves way for revolution in treatment of genetic disorders
The development of an investigational therapy which 'edits' a harmful gene in patients with a debilitating condition called amyloidosis could pave the way for a revolution in the treatment of genetic disorders, finds a new study led by UCL scientists.
The development of an investigational therapy which 'edits' a harmful gene in patients with a debilitating condition called amyloidosis could pave the way for a revolution in the treatment of genetic disorders, finds a new study led by UCL scientists.
Ground-breaking lung cancer trial gets under way
The first participants have taken part in a ground-breaking research trial that aims to save lives by improving the early diagnosis of lung cancer.
The first participants have taken part in a ground-breaking research trial that aims to save lives by improving the early diagnosis of lung cancer.
COVID: The three barriers that stop people being vaccinated
Getting everyone in a country vaccinated is like watching software updates load: it whizzes along for the first 80% or so and then seems to take forever to finish the rest.
Getting everyone in a country vaccinated is like watching software updates load: it whizzes along for the first 80% or so and then seems to take forever to finish the rest.
A low-cost life support machine for patients with covid
A device that helps desperately sick patients breathe- and- costs around £150 to manufacture- could revolutionise access -to life-saving care in low to middle income countries.
A device that helps desperately sick patients breathe- and- costs around £150 to manufacture- could revolutionise access -to life-saving care in low to middle income countries.
RECOVERY trial Regeneron’s monoclonal antibody combination reduces deaths for hospitalised COVID-19 patients
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial has demonstrated that the investigational antibody combination developed by Regeneron reduces the risk of death when given to patients hospitalised with severe COVID-19 who have not mounted a natural antibody response of their own. The treatment uses a combination of two monoclonal antibodies (casirivimab and imdevimab, known as REGEN-COV in the US) that bind specifically to two different sites on the coronavirus spike protein, neutralising the ability of the virus to infect cells.
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial has demonstrated that the investigational antibody combination developed by Regeneron reduces the risk of death when given to patients hospitalised with severe COVID-19 who have not mounted a natural antibody response of their own. The treatment uses a combination of two monoclonal antibodies (casirivimab and imdevimab, known as REGEN-COV in the US) that bind specifically to two different sites on the coronavirus spike protein, neutralising the ability of the virus to infect cells.
Treating Needle Fears May Reduce COVID-19 Vaccine Hesitancy Rates by 10%
A new large-scale study shows that a quarter of the UK adult population screens positive for a potential injection phobia.
A new large-scale study shows that a quarter of the UK adult population screens positive for a potential injection phobia.
GW4 takes a world leading One Health approach to tackling the antimicrobial resistance pandemic
New alliance brings together academic expertise looking at all aspects of antimicrobial resistance from public health to agriculture.
New alliance brings together academic expertise looking at all aspects of antimicrobial resistance from public health to agriculture.
Major new study could help protect millions of people with type 2 diabetes from cardiovascular disease | University of Oxford
A new study led by the Nuffield Department of Population Health at the will research whether a daily tablet could help protect the millions of people worldwide with type 2 diabetes from developing cardiovascular disease.
A new study led by the Nuffield Department of Population Health at the will research whether a daily tablet could help protect the millions of people worldwide with type 2 diabetes from developing cardiovascular disease.
Averting an antibiotics apocalypse: major funding announced to tackle resistance to antibiotics
A cross-disciplinary team from the Universities of Oxford, Ulster and UCL today announced major funding from EPSRC, part of UK Research and Innovation (UKRI), to tackle the growing challenge of Antimicrobial Resistance (AMR).
A cross-disciplinary team from the Universities of Oxford, Ulster and UCL today announced major funding from EPSRC, part of UK Research and Innovation (UKRI), to tackle the growing challenge of Antimicrobial Resistance (AMR).
Event - Today
Erin James, University of Sussex's 'Stuart Hall Fellow', to perform at Brighton Festival
Erin James, University of Sussex's 'Stuart Hall Fellow', to perform at Brighton Festival
Innovation - Today
National Grid and University of Manchester pilot drone-mounted electric field sensors for pylon inspections
National Grid and University of Manchester pilot drone-mounted electric field sensors for pylon inspections