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Pharmacology
Results 101 - 150 of 658.
Led team wins time on world’s most powerful computer
A UCL-led team of researchers is using the world's first exascale computer to identify a shortlist of potential new drugs for diseases and to better understand how stroke affects the brain. The supercomputer, Frontier, at the Oak Ridge Leadership Computing Facility in Tennessee, US, is the first in the world capable of an exaflop - a billion billion operations a second.
A UCL-led team of researchers is using the world's first exascale computer to identify a shortlist of potential new drugs for diseases and to better understand how stroke affects the brain. The supercomputer, Frontier, at the Oak Ridge Leadership Computing Facility in Tennessee, US, is the first in the world capable of an exaflop - a billion billion operations a second.
Trial of innovative CAR-T blood cancer treatment expanded
A clinical trial of a personalised therapy for blood cancer, led by researchers at UCL and University College London Hospitals, has been expanded enabling new groups of patients with a wider range of blood cancers to now receive the treatment. The new type of CAR T-cell therapy - where a patient's own immune system is 'reprogrammed' in order to fight their cancer - has already been shown to have promise for adult patients with a type of blood cancer called relapsed B-cell acute lymphoblastic leukaemia (B-ALL).
A clinical trial of a personalised therapy for blood cancer, led by researchers at UCL and University College London Hospitals, has been expanded enabling new groups of patients with a wider range of blood cancers to now receive the treatment. The new type of CAR T-cell therapy - where a patient's own immune system is 'reprogrammed' in order to fight their cancer - has already been shown to have promise for adult patients with a type of blood cancer called relapsed B-cell acute lymphoblastic leukaemia (B-ALL).
6 amazing scientific achievements at Imperial in 2022
From exploring magic mushrooms to answering COVID-19 questions, here are some of Imperial's biggest findings this year: Psilocybin "opens up" the brains of people with depression Psilocybin, the psychedelic component of magic mushrooms, was shown in April to increase brain connectivity in people with depression.
From exploring magic mushrooms to answering COVID-19 questions, here are some of Imperial's biggest findings this year: Psilocybin "opens up" the brains of people with depression Psilocybin, the psychedelic component of magic mushrooms, was shown in April to increase brain connectivity in people with depression.
What Imperial research taught us about COVID-19 in 2022
From increased understanding of immunity to analysing the success of vaccines, we look back at what Imperial taught us about COVID-19 in 2022. Omicron infection doesn't boost immunity much A study published in March in the journal Science found that in triple-vaccinated people infected for the first time, Omicron infection boosted immunity against previous variants (such as alpha, delta, and the original strain) but less so against Omicron.
From increased understanding of immunity to analysing the success of vaccines, we look back at what Imperial taught us about COVID-19 in 2022. Omicron infection doesn't boost immunity much A study published in March in the journal Science found that in triple-vaccinated people infected for the first time, Omicron infection boosted immunity against previous variants (such as alpha, delta, and the original strain) but less so against Omicron.
University of Glasgow cancer experts to receive £1.7m from Cancer Research UK
University of Glasgow scientists are to receive £1.7m from Cancer Research UK to investigate both the root causes of cancer and how treatments can be improved. Professor Stephen Tait, of the Cancer Research UK Beatson Institute and the Glasgow University School of Cancer Sciences, will receive £1,646,832 to investigate what causes cancer cells to grow out of control and form tumours.
University of Glasgow scientists are to receive £1.7m from Cancer Research UK to investigate both the root causes of cancer and how treatments can be improved. Professor Stephen Tait, of the Cancer Research UK Beatson Institute and the Glasgow University School of Cancer Sciences, will receive £1,646,832 to investigate what causes cancer cells to grow out of control and form tumours.
Racism is ’fundamental cause’ of COVID-19 vaccine hesitancy among ethnic minorities
Racism is the 'fundamental cause' of COVID-19 vaccination hesitancy among ethnic minority groups, according to a newly published briefing from the Runnymede Trust and The University of Manchester's Centre on the Dynamics of Ethnicity. During the rollout of the COVID-19 vaccination programme in the UK, explanations for the lower vaccination rates in people from ethnic minority groups focused on differences in the level of concern about side effects and in a lack of trust in the development and efficacy of the vaccine.
Racism is the 'fundamental cause' of COVID-19 vaccination hesitancy among ethnic minority groups, according to a newly published briefing from the Runnymede Trust and The University of Manchester's Centre on the Dynamics of Ethnicity. During the rollout of the COVID-19 vaccination programme in the UK, explanations for the lower vaccination rates in people from ethnic minority groups focused on differences in the level of concern about side effects and in a lack of trust in the development and efficacy of the vaccine.
One in five GPs unwilling to prescribe aspirin to people at risk of bowel cancer
One in five GPs could be unwilling to prescribe aspirin to patients with a cancer-causing syndrome, despite national guidelines advising it, new research has found.
One in five GPs could be unwilling to prescribe aspirin to patients with a cancer-causing syndrome, despite national guidelines advising it, new research has found.
World-first genetic test for babies’ hearing wins major award
A team who led the research for a world-first genetic test that could save the hearing of hundreds of babies each year, has won the New Statesman Positive Impact in Healthcare Award 2022.
A team who led the research for a world-first genetic test that could save the hearing of hundreds of babies each year, has won the New Statesman Positive Impact in Healthcare Award 2022.
World-first use of base-edited CAR T-cells to treat resistant leukaemia
A patient with relapsed T-cell leukaemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).
A patient with relapsed T-cell leukaemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).
Opinion: China could face a catastrophic COVID surge as it lifts restrictions
Following China's strict zero-COVID strategy, Professor Francois Balloux (UCL Biosciences) warns in The Conversation about the risk of a likely surge in infections as restrictions ease.
Following China's strict zero-COVID strategy, Professor Francois Balloux (UCL Biosciences) warns in The Conversation about the risk of a likely surge in infections as restrictions ease.
Key to supercharging immunotherapy’s ability to stop breast cancer spreading to the lung
Glasgow scientists discover key to supercharging immunotherapy's ability to stop breast cancer spreading to the lung Breast cancer immunotherapy could be more effective if an immune cell that prevents it from working is targeted at the same time, according to new Breast Cancer Now and Secondary1st funded research from the University of Glasgow.
Glasgow scientists discover key to supercharging immunotherapy's ability to stop breast cancer spreading to the lung Breast cancer immunotherapy could be more effective if an immune cell that prevents it from working is targeted at the same time, according to new Breast Cancer Now and Secondary1st funded research from the University of Glasgow.
Multi-million-pound trial will help rapidly find flu treatments this winter
A new national trial, launched today, aims to use pandemic lessons to help quickly find effective treatments for people hospitalised with severe flu.
A new national trial, launched today, aims to use pandemic lessons to help quickly find effective treatments for people hospitalised with severe flu.
Blood thinning drug to treat recovery from severe COVID-19 is not effective
A drug used to reduce the risk of blood clots does not help patients recovering from moderate and severe COVID-19, despite this approach being offered to patients, a UK-wide trial, led by Addenbrooke's Hospital and the University of Cambridge has found.
A drug used to reduce the risk of blood clots does not help patients recovering from moderate and severe COVID-19, despite this approach being offered to patients, a UK-wide trial, led by Addenbrooke's Hospital and the University of Cambridge has found.
Precision medicine trial opens for rare adult and paedatric cancers
Cancer Research UK, The University of Manchester and Roche Products Ltd ('Roche'), today (Wednesday 23rd), announce that they have opened a multi-drug, precision medicine trial for people with rare cancers who need more treatment options.
Cancer Research UK, The University of Manchester and Roche Products Ltd ('Roche'), today (Wednesday 23rd), announce that they have opened a multi-drug, precision medicine trial for people with rare cancers who need more treatment options.
Sequencing project to unleash the biotechnology potential of single-celled algae
An ambitious plan to sequence the genomes of all known species of euglenoids over the next decade has been launched today.
An ambitious plan to sequence the genomes of all known species of euglenoids over the next decade has been launched today.
Recruitment milestone reached in breast cancer trial
A milestone 3,000 participants have been recruited to a clinical trial led by UCL and UCLH, which is aimed at reducing the number of patients with breast cancer who receive unnecessary chemotherapy.
A milestone 3,000 participants have been recruited to a clinical trial led by UCL and UCLH, which is aimed at reducing the number of patients with breast cancer who receive unnecessary chemotherapy.
NHS must learn to love smart IV pumps to avoid drug errors
Hospitals must start using "smart" intravenous (IV) infusion technology to its full potential if they are to prevent dangerous drug errors, University of Manchester researchers have found.
Hospitals must start using "smart" intravenous (IV) infusion technology to its full potential if they are to prevent dangerous drug errors, University of Manchester researchers have found.
Pandemic Sciences Institute formally launched in Oxford
The University of Oxford's Pandemic Sciences Institute (PSI) has been formally launched at a two-day event at the Blavatnik School of Government, at which the lead researchers set out its direction and strategy for the next five years.
The University of Oxford's Pandemic Sciences Institute (PSI) has been formally launched at a two-day event at the Blavatnik School of Government, at which the lead researchers set out its direction and strategy for the next five years.
Interrupting the treatment of vulnerable people on immune-suppressing medicines, doubles their antibody response to COVID-19 booster vaccination
A major clinical trial, led by experts at the University of Nottingham working in partnership with Universities and NHS hospitals including the University of Manchester , has found that by interrupting the treatment of vulnerable people on long-term immune suppressing medicines for two weeks after a COVID-19 booster vaccination, their antibody response to the jab is doubled.
A major clinical trial, led by experts at the University of Nottingham working in partnership with Universities and NHS hospitals including the University of Manchester , has found that by interrupting the treatment of vulnerable people on long-term immune suppressing medicines for two weeks after a COVID-19 booster vaccination, their antibody response to the jab is doubled.
Which patients with advanced prostate cancer will benefit from chemotherapy
Researchers have recommended changes to how cancer patients are treated, after a new UCL-led study discovered that chemotherapy is significantly more effective for some men with advanced prostate cancer than others.
Researchers have recommended changes to how cancer patients are treated, after a new UCL-led study discovered that chemotherapy is significantly more effective for some men with advanced prostate cancer than others.
COPD patients respond equally well to COVID-19 vaccine
A study which tested the immune response of COPD patients to COVID-19 vaccination has shown they respond in a similar way to healthy people.
A study which tested the immune response of COPD patients to COVID-19 vaccination has shown they respond in a similar way to healthy people.
Heart surgery delays will cost lives, warns research
Pandemic has delayed lifesaving treatment for thousands of people with severe aortic stenosis. Our approach does not put the onus on only management or doctors, but creates a joint solution that is easier to implement in practice Feryal Erhun Urgent action is needed to clear the backlog of people with a common heart condition who are waiting for lifesaving treatment, according to published in the journal BMJ Open .
Pandemic has delayed lifesaving treatment for thousands of people with severe aortic stenosis. Our approach does not put the onus on only management or doctors, but creates a joint solution that is easier to implement in practice Feryal Erhun Urgent action is needed to clear the backlog of people with a common heart condition who are waiting for lifesaving treatment, according to published in the journal BMJ Open .
New system that defines Huntington’s Disease will ’revolutionise’ drug trials
A novel staging framework that assesses the progression of Huntington's disease (HD), similar to the way cancer is staged 0 to 4, has been developed by UCL scientists as part of an international consortium; paving the way for clinical trials of drugs in the earliest stages of HD.
A novel staging framework that assesses the progression of Huntington's disease (HD), similar to the way cancer is staged 0 to 4, has been developed by UCL scientists as part of an international consortium; paving the way for clinical trials of drugs in the earliest stages of HD.
Researchers in Glasgow to receive £1.9m to tackle late stage cancer syndrome
Scientists at the Cancer Research UK Beatson Institute and the University of Glasgow are to receive £1.9m to explore the causes of a debilitating wasting disease that many people experience in the later stages of cancer. The funding is from Cancer Grand Challenges, a research initiative co-founded by Cancer Research UK and the National Cancer Institute in the US, which aims to encourage the world's leading researchers to tackle the toughest challenges faced by cancer patients.
Scientists at the Cancer Research UK Beatson Institute and the University of Glasgow are to receive £1.9m to explore the causes of a debilitating wasting disease that many people experience in the later stages of cancer. The funding is from Cancer Grand Challenges, a research initiative co-founded by Cancer Research UK and the National Cancer Institute in the US, which aims to encourage the world's leading researchers to tackle the toughest challenges faced by cancer patients.
UK researchers pioneer new virtual treatment for PTSD
Researchers at Cardiff University have pioneered a new form of virtual treatment for people with post-traumatic stress disorder (PTSD).
Researchers at Cardiff University have pioneered a new form of virtual treatment for people with post-traumatic stress disorder (PTSD).
COVID-19 and Brexit ’caused sharp rise in copycat ecstasy’
A new study has highlighted the apparent effect of Brexit and the pandemic on the trade in the illegal party drug ecstasy (MDMA). Researchers from The Loop, a UK drug checking charity, found almost half (45%) of substances sold as MDMA at English festivals last year contained none - and instead contained other drugs such as caffeine or cathinones.
A new study has highlighted the apparent effect of Brexit and the pandemic on the trade in the illegal party drug ecstasy (MDMA). Researchers from The Loop, a UK drug checking charity, found almost half (45%) of substances sold as MDMA at English festivals last year contained none - and instead contained other drugs such as caffeine or cathinones.
Study identifies best treatment for rare childhood cancer
High doses of drug called ifosfamide are the best way to treat a cancer of children which affects bones and soft tissues, compared to three other treatments, according to University of Manchester researchers.
High doses of drug called ifosfamide are the best way to treat a cancer of children which affects bones and soft tissues, compared to three other treatments, according to University of Manchester researchers.
University spinout in major partnership to commercialize treatment for invasive aspergillosis
F2G, a University of Manchester spinout company, is to partner a major Japanese pharmaceutical company in the commercialisation of a novel antifungal treatment it developed for invasive aspergillosis and other rare mould infections.
F2G, a University of Manchester spinout company, is to partner a major Japanese pharmaceutical company in the commercialisation of a novel antifungal treatment it developed for invasive aspergillosis and other rare mould infections.
Robotic surgery is safer and improves patient recovery time
Robot-assisted surgery used to perform bladder cancer removal enables patients to recover far more quickly and spend significantly (20 per cent) less time in hospital, concludes a first-of-its kind clinical trial led by scientists at UCL and the University of Sheffield.
Robot-assisted surgery used to perform bladder cancer removal enables patients to recover far more quickly and spend significantly (20 per cent) less time in hospital, concludes a first-of-its kind clinical trial led by scientists at UCL and the University of Sheffield.
Spotlight on... Professor Jayant S Vaidya
This week Jayant, Professor of Surgery and Oncology at UCL Division of Surgery, shares the story of how he helped to develop a pioneering new treatment for breast cancer, which is featured as a case study in UCL's latest REF submission.
This week Jayant, Professor of Surgery and Oncology at UCL Division of Surgery, shares the story of how he helped to develop a pioneering new treatment for breast cancer, which is featured as a case study in UCL's latest REF submission.
New report outlines vision for safe, effective and accessible medicines in pregnancy
A UK-first report into the state of pregnancy medicine, which was co-commissioned by Professor Anna David (UCL EGA Institute for Women's Health), has proposed a clear roadmap to help reduce the high number of needless newborn deaths and improve maternal health.
A UK-first report into the state of pregnancy medicine, which was co-commissioned by Professor Anna David (UCL EGA Institute for Women's Health), has proposed a clear roadmap to help reduce the high number of needless newborn deaths and improve maternal health.
Guidance on living safely with infections
The Government has removed the remaining domestic COVID-19 restrictions in England - find out about our updated advice for living safely with respiratory infections including COVID-19.
The Government has removed the remaining domestic COVID-19 restrictions in England - find out about our updated advice for living safely with respiratory infections including COVID-19.
Major new investment in clinical research at UCL
Pioneering clinical research carried out at UCL will benefit from almost £12m in new funding, thanks to a major investment by University College London Hospitals NHS Foundation Trust (ULCH).
Pioneering clinical research carried out at UCL will benefit from almost £12m in new funding, thanks to a major investment by University College London Hospitals NHS Foundation Trust (ULCH).
New ovarian cancer study to determine mechanism behind treatment resistance
A new research project led by the Univerity of Glasgow and funded by leading health charity Wellbeing of Women, in partnership with Artios Pharma Limited (Artios), will investigate why some advanced ovarian cancers become resistant to a new type of treatment called PARP inhibitors.
A new research project led by the Univerity of Glasgow and funded by leading health charity Wellbeing of Women, in partnership with Artios Pharma Limited (Artios), will investigate why some advanced ovarian cancers become resistant to a new type of treatment called PARP inhibitors.
Scientists use vaccination to successfully treat COVID-19 for first time
Doctors have successfully used vaccination to treat a patient with COVID-19 in what is thought to be the first instance of the vaccine being used for therapy instead of prevention.
Doctors have successfully used vaccination to treat a patient with COVID-19 in what is thought to be the first instance of the vaccine being used for therapy instead of prevention.
Vitamin B3 trialled as glaucoma treatment
A major four-year clinical trial to test the effectiveness of nicotinamide (NAM), a form of vitamin B3, as a treatment for glaucoma is to be led by UCL and Moorfields Eye Hospital researchers.
A major four-year clinical trial to test the effectiveness of nicotinamide (NAM), a form of vitamin B3, as a treatment for glaucoma is to be led by UCL and Moorfields Eye Hospital researchers.
New guidelines for endometriosis set to help millions of women with chronic condition
Scientists from UCL and UCLH have informed a new set of clinical guidelines to aid better diagnosis and management of endometriosis - a chronic condition that causes severe pelvic pain and reduced fertility for millions of women worldwide.
Scientists from UCL and UCLH have informed a new set of clinical guidelines to aid better diagnosis and management of endometriosis - a chronic condition that causes severe pelvic pain and reduced fertility for millions of women worldwide.
Global study launched to evaluate effects of Covid-19 variants and vaccination in pregnancy
INTERCOVID-2022: The University of Oxford is to launch the 2022 round of the global study to evaluate the effects of Covid-19 variants and vaccination in pregnancy.
INTERCOVID-2022: The University of Oxford is to launch the 2022 round of the global study to evaluate the effects of Covid-19 variants and vaccination in pregnancy.
History - Oct 2
Stories, History, and Poetry: Being Human Festival presents a diverse Scottish line-up
Stories, History, and Poetry: Being Human Festival presents a diverse Scottish line-up
Physics - Oct 2
Opinion: Think before shouting at your child: to them, words can be as harmful as physical blows
Opinion: Think before shouting at your child: to them, words can be as harmful as physical blows

Pharmacology - Oct 2
Oxford R21/Matrix-M(TM) malaria vaccine receives WHO recommendation for use paving the way for global roll-out
Oxford R21/Matrix-M(TM) malaria vaccine receives WHO recommendation for use paving the way for global roll-out
Career - Oct 2
Poverty, unemployment, terrorism and global kleptocracy celebrated for real-world impacts
Poverty, unemployment, terrorism and global kleptocracy celebrated for real-world impacts
Environment - Oct 2
Innovative flood resilience project announced as ESRC Celebrating Impact Prize Finalist
Innovative flood resilience project announced as ESRC Celebrating Impact Prize Finalist