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Results 41 - 60 of 824.


Health - Pharmacology - 11.01.2024
MRNA technology could be possible treatment for rare diseases
MRNA technology could be possible treatment for rare diseases
By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people. The research, published in Science Translational Medicine , found that messenger RNA (mRNA) could be used to correct a rare liver genetic disease known as argininosuccinic aciduria in a mouse model of the disease.

Health - Pharmacology - 09.01.2024
82% of asthma hospitalisations not getting recommended two-day follow-up
Epidemiological study shows significant numbers of asthma patients not receiving standard level of care, and worse for black patients Asthma patients who ended up in hospital only had a GP appointment within recommended 48-hour period in 18% of cases between 2017-19, new research shows. New data published in the British Journal of General Practice looked at electronic healthcare records from more than 17,000 patients over the age of five.

Health - Pharmacology - 18.12.2023
’Unclear’ whether opioids are effective at treating cancer pain
The world's largest review on opioid medicines for cancer pain has found it is unclear whether some commonly used opioid medicines are better than a placebo and suggests that non-opioid medicines, including aspirin, may be as effective as opioids. Researchers examining the data on opioids for pain caused by cancer have found surprisingly large gaps in evidence regarding the true benefits of these medicines for cancer pain.

Health - Pharmacology - 06.12.2023
Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses
Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent 'off-target' immune responses to enable the safer design of future mRNA therapeutics.

Health - Pharmacology - 05.12.2023
Individually targeted therapies may improve treatment for psychosis
A paper from the University of Southampton examining how best to treat psychosis has concluded that a greater range of individually targeted therapies could improve outcomes for patients. The research questions if Cognitive Behaviour Therapy (CBTp) for psychosis should remain the dominant treatment and suggests that, in the future, big data and artificial intelligence may help to develop a range of more bespoke therapies.

Health - Pharmacology - 30.11.2023
Study identifies barriers that limit young men at HIV risk from taking preventative drug
A new qualitative study from Bath psychologists suggests a lack of information and perceived necessity, as well as awkwardness, are impacting uptake of PrEP. Published on Thursday 30 November 2023 Last updated on Thursday 30 November 2023 Results of a qualitative research study into the uptake of PrEP - a drug which stops HIV infecting the body - suggests that more needs to be done to breakdown barriers to access for the potentially lifesaving medication.

Health - Pharmacology - 29.11.2023
New target identified for drugs to treat cancer and age-related diseases
New target identified for drugs to treat cancer and age-related diseases
Insights that pave the way for novel therapeutic approaches to tackle cancer, fibrosis, and many age-related conditions have been uncovered by a team of scientists, including researchers from UCL. The research, published in Nature Cell Biology and led by the Laboratory of Medical Sciences (MRC-LMS), identifies a new target for a class of drugs that selectively eliminate cells that are known to provoke inflammation.

Life Sciences - Pharmacology - 28.11.2023
Scientists harness flower 'super power' to pave the way for new drug treatments
Scientists harness flower ’super power’ to pave the way for new drug treatments
Researchers from the Department of Life Sciences have developed a way of joining up the ends of proteins, making them more stable and easier to get into cells. Published on Tuesday 28 November 2023 Last updated on Wednesday 6 December 2023 Scientists at the University of Bath have used nature as inspiration in developing a new tool that will help researchers develop new pharmaceutical treatments in a cleaner, greener, and less expensive way.

Health - Pharmacology - 27.11.2023
Early-stage stem cell therapy trial shows promise for treating progressive MS
An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

Health - Pharmacology - 24.11.2023
Prostate cancer focal therapy is cost effective and may improve patient outcomes
Minimally invasive focal therapies for prostate cancer are associated with a lower overall cost and improved quality of life for patients. These are the findings of a new study , published recently in the Journal of Medical Economics, and led by researchers from Imperial College London. It shows that when compared to surgery or radiotherapy, focal therapies for prostate cancer such as cryotherapy and High Intensity Focused Ultrasound (HIFU) are associated with a lower overall cost and improved quality of life.

Health - Pharmacology - 23.11.2023
Study links deprivation with risk of dying from sepsis
The most socioeconomically deprived groups in society are nearly twice as likely to die from sepsis within 30 days, researchers from The University of Manchester have found. The study of NHS data analysed 248,767 cases of non-COVID-19 sepsis from January 2019, to June, 2022 matched with 1,346,166 controls.

Pharmacology - Health - 21.11.2023
Clinical trial results give new hope for children with rare gliomas
Clinical trial results give new hope for children with rare gliomas
A collaboration of researchers, led by UCL and Great Ormond Street Hospital, have published successful results from a Phase II clinical trial for the treatment of BRAF mutated low-grade paediatric gliomas. Gliomas are cancerous brain tumours that start in glial cells - the supporting cells of the brain.

Health - Pharmacology - 17.11.2023
AI can detect antibiotic resistance in as little as 30 minutes
To mark World Antimicrobial Awareness Week , researchers supported by the Oxford Martin Programme on Antimicrobial Resistance Testing at the University of Oxford have reported advances towards a novel and rapid antimicrobial susceptibility test that can return results within as little as 30 minutes - significantly faster than current gold-standard approaches.

Health - Pharmacology - 16.11.2023
Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia
Lab-grown ’small blood vessels’ point to potential treatment for major cause of stroke and vascular dementia
Cambridge scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.

Pharmacology - Innovation - 16.11.2023
New device and drug combination will revolutionise heart failure treatment
A newly-developed heart failure device and medication combination is safe and effective to use, and will allow patients to receive treatment from the comfort of their own home A newly-developed heart failure device and medication combination is safe and effective to use, and will allow patients to receive treatment from the comfort of their own home.

Health - Pharmacology - 16.11.2023
First effective treatment to prevent multidrug-resistant TB
First effective treatment to prevent multidrug-resistant TB
An oral antibiotic taken once daily for six months can substantially reduce the risk of developing multidrug-resistant (MDR) tuberculosis (TB) in both children and adults, according to two landmark clinical trials involving UCL researchers. The results were announced at the Union World Conference on Lung Health in Paris.

Health - Pharmacology - 13.11.2023
Heart attack risk decreased in new mothers by self-monitoring blood pressure at home
Self-monitoring blood pressure after giving birth could help to cut new mothers' risk of future heart disease and strokes, according to new research by Oxford researchers. The study, funded by the BHF and supported by the NIHR Oxford Biomedical Research Centre (BRC) , could be the first step towards blood pressure self-monitoring becoming routinely recommended for women who have high blood pressure during pregnancy, to prevent future health problems.

Pharmacology - Health - 11.11.2023
Heart stents may offer alternative to chest pain medication for angina patients
Heart stents may offer alternative to chest pain medication for angina patients
Some patients with chest pain from reduced blood flow to the heart may benefit from having a stent implanted, instead of chest pain medications. These are the findings of a study, led by researchers at Imperial College London and Imperial College Healthcare NHS Trust, which evaluated the impact of stents on reducing pain in patients with angina.

Health - Pharmacology - 08.11.2023
Artificial bladders shine light on bugs that cause urinary tract infections
Artificial bladders shine light on bugs that cause urinary tract infections
A new study led by UCL researchers reveals that numerous bacterial strains are capable of hiding in the human bladder wall, suggesting why urinary tract infections often persist after treatment. The research, published today in Science Advances , is the first to use a sophisticated human tissue model to explore the interaction between host and pathogen for six common species that cause urinary tract infections.

Health - Pharmacology - 01.11.2023
Cancer drug could hold hope for treating inflammatory diseases including gout and heart diseases
A cancer drug currently in the final stages of clinical trials could offer hope for the treatment of a wide range of inflammatory diseases, including gout, heart failure, cardiomyopathy, and atrial fibrillation, say scientists at the University of Cambridge.