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Pharmacology - Health - 26.05.2022
Common drug-resistant superbug develops fast resistance to 'last resort' antibiotic
Common drug-resistant superbug develops fast resistance to ’last resort’ antibiotic
New research has found that Pseudomonas bacterium develops resistance much faster than usual to a common 'last-resort' antibiotic. A study published today in Cell Reports reveals how populations of a bacterium called Pseudomonas respond to being treated with Colistin, a 'last resort' antibiotic for patients who have developed multi-drug resistant infections.

Health - Pharmacology - 24.05.2022
Population-scale study highlights ongoing risk of COVID-19 in some cancer patients despite vaccination
Population-scale study highlights ongoing risk of COVID-19 in some cancer patients despite vaccination
The UK Coronavirus Cancer Evaluation Project has delivered the world's largest analysis of the effect of COVID-19 vaccination on people with cancer.

Health - Pharmacology - 23.05.2022
Heart Inflammation found in 1 in 8 patients after hospitalisation with COVID-19
One in eight people who were hospitalised with COVID-19 between May 2020 and March 2021 were later diagnosed with myocarditis, or heart inflammation, according to major new research into the clinical long-term effects of COVID-19. The largest study of its kind to date was led by the University of Glasgow in collaboration with NHS Greater Glasgow and Clyde (NHS GGC), and followed for one year, in real time, 159 patients after they were hospitalised with COVID-19.

Health - Pharmacology - 19.05.2022
New reporting guidelines developed to improve AI in healthcare settings
New reporting guidelines, jointly published and the BMJ by Oxford researchers, will ensure that early studies on using Artificial Intelligence (AI) to treat real patients will give researchers the information needed to develop AI systems safely and effectively. Artificial Intelligence in medicine has shown promising results in numerous simulation studies, but very few AI systems have yet been used in patient care.

Health - Pharmacology - 18.05.2022
Antibiotics given shortly before caesarean birth not linked to asthma and eczema in young children
Antibiotics given to women before a caesarean birth have no effect on the risk of early childhood conditions, such as asthma or eczema, suggests a study by researchers at the Universities of Warwick and Birmingham. The research, published today (18 May 2022) in The BMJ, and funded by the National Institute for Health and Care Research, provides further evidence to support recommendations made by the National Institute for Health and Care Excellence (NICE).

Environment - Pharmacology - 05.05.2022
Our lifestyles are key contributors to river pollution - here is how social prescribing can help
Our lifestyles are key contributors to river pollution - here is how social prescribing can help
Home and lifestyle activities are major contributors to water quality. Social interventions may provide the most sustainable solution. Household and lifestyle activities are key contributors to water quality, according to new research from the University of Bath. Social interventions - such as social prescribing - may provide a more sustainable solution to this problem than improvements to wastewater treatment processes.

Health - Pharmacology - 04.05.2022
Krill oil may be beneficial to muscle function and size, in people over 65
Krill oil may be beneficial to muscle function and size in healthy people over the age of 65, according to new research. The study - led by the University of Glasgow's Institute of Cardiovascular and Medical Sciences (ICAMS) and published in Clinical Nutrition - found that krill oil supplementation of four grams per day could have beneficial effects on skeletal muscle function and size in this age group.

Psychology - Pharmacology - 26.04.2022
Talk therapy may alleviate depression and improve quality of life for people with dementia
Talk therapy may alleviate depression and improve quality of life for people with dementia
Talking therapies may improve symptoms of depression for people with dementia, finds a new review led by UCL researchers, providing hope for a group who typically do not benefit from antidepressants. Feelings of anxiety and depression are common in people living with dementia and mild cognitive impairment, but the best way to treat these symptoms is currently unknown, as medicines often used to treat these symptoms may not be effective for people with dementia and may cause side effects.

Health - Pharmacology - 22.04.2022
Make-up of SARS-CoV-2 outer envelope for first time
Scientists from Cardiff University have detailed the molecular make-up of the fatty outer envelope of SARS-CoV-2 for the first time - and say it could prove an important new target for antivirals. The team's work on the viral lipid envelope showed it had significant differences to healthy host cell membranes, suggesting the potential for it to be selectively targeted.

Health - Pharmacology - 19.04.2022
Maximising the effectiveness of therapeutic vaccines a step closer
Maximising the effectiveness of therapeutic vaccines a step closer
Scientists at UCL have significantly boosted the effectiveness of a therapeutic vaccine designed to control chronic hepatitis B (HBV) infection, after uncovering and thwarting 'the enemy within'. Published in Science Translational Medicine , researchers say the findings in mice are a breakthrough in the field of vaccine development, as they reveal how to enhance the antiviral T cell response that therapeutic vaccines are intended to trigger.

Health - Pharmacology - 12.04.2022
How Covid-19 triggers massive inflammation revealed
How Covid-19 triggers massive inflammation revealed
The reasons why Covid-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage, has been revealed in a new study involving a UCL scientist. Published in Nature , the study led by researchers at Boston Children's Hospital (US) , found evidence that the virus might activate inflammasomes, large molecules that trigger a cascade of inflammatory responses that ends in cell death.

Health - Pharmacology - 07.04.2022
Covid-19 vaccine uptake among minority groups was driven by mistrust
Covid-19 vaccine uptake among minority groups was driven by mistrust
Lower Covid-19 vaccine uptake among Black ethnic groups in London compared to White British groups was driven by trust, including mistrust in the vaccine itself and in authorities administering it, according to research led by UCL. The peer-reviewed study, published in the Journal of Public Health, was undertaken by UCL researchers funded by National Institute of Health and Care Research (NIHR) ARC North Thames, in collaboration with the Government's Office for Health Improvement and Disparities, the UK Health Security Agency (UKHSA) as well as other London partners.

Pharmacology - Health - 31.03.2022
Global disparities persist in opioid painkiller access
Global disparities persist in opioid painkiller access
Global opioid sales increased by an estimated 4% annually from 2015 to 2019, but massive disparities in access to essential pain relief medications persist between countries, finds a study led by UCL researchers. Opioid use in some countries in Africa and South America was less than one tenth of 1% of the rates in wealthier countries in North America, Europe and Australia, according to the findings published in The Lancet Public Health .

Innovation - Pharmacology - 25.03.2022
Medicines 3D-printed in seven seconds
Medicines 3D-printed in seven seconds
Medicines can be printed in seven seconds in a new 3D-printing technique that could enable rapid on-site production of medicines, reports a UCL-led research team. The findings published in the journal, Additive Manufacturing , improve the prospects of how 3D printers could be integrated into fast-paced clinical settings for on-demand production of personalised medicines.

Health - Pharmacology - 18.03.2022
Vaccine effectiveness wanes after three months among care home residents
Vaccine effectiveness wanes after three months among care home residents
Vaccination-acquired immunity against Covid-19 wanes substantially after three months among elderly care home residents, suggesting that regular booster jabs may be needed for this group, according to preliminary findings from the Vivaldi study led by UCL researchers. The study, funded by the UK Health Security Agency  and published on the preprint site medRxiv, looked at data from over 15,000 residents (with a median age of 87) and 19,000 staff at 331 care homes across England from December 2020 to December 2021.

Health - Pharmacology - 17.03.2022
World-first CJD treatment shows promising early results
World-first CJD treatment shows promising early results
A world-first treatment for Creutzfeldt-Jakob disease (CJD), developed by scientists at the Medical Research Council (MRC) Prion Unit at UCL, has shown "very encouraging" early results following its use in six patients at University College London Hospitals (UCLH) NHS Foundation. CJD is a rare but devastating disease that causes brain damage and for which there is currently no licensed treatment.

Health - Pharmacology - 16.03.2022
Mandatory vaccinations not the answer to boosting uptake among NHS staff
Mandatory vaccinations not the answer to boosting uptake among NHS staff
Just one in six (18%) healthcare workers thought mandatory vaccinations were the best solution to encourage more frontline staff to have a Covid-19 jab, finds new research led by UCL and the University of Leicester. As part of the UK-REACH longitudinal study, researchers carried out a survey of over 3,200 NHS healthcare workers, to understand how they felt about mandatory vaccinations, and find out what solutions they may have to address the problem of under-vaccination among colleagues.

Health - Pharmacology - 16.03.2022
Frailty may be reversible for some people with rheumatoid arthritis
Frailty may be reversible for some people with rheumatoid arthritis
Rheumatoid arthritis patients living with frailty may find their frailty is reversible following treatment, according to a new study. The research, published in RMD Open and led by the University of Glasgow, looked at frailty - a vulnerability to poor health-outcomes - in people with rheumatoid arthritis (RA).

Health - Pharmacology - 11.03.2022
Superhuman 20 second AI heart tool begins NHS roll-out
Superhuman 20 second AI heart tool begins NHS roll-out
A new artificial intelligence (AI) tool developed by UCL researchers can be used to detect heart disease in record speed, helping to improve care for heart patients. The first-of-its-kind AI tool, described in a new paper in the Journal of Cardiovascular Magnetic Resonance , analyses heart MRI scans in just 20 seconds whilst the patient is in the scanner.

Pharmacology - Health - 07.03.2022
Covid-19 vaccine rollout worsened existing health inequalities, find researchers
Covid-19 vaccine rollout worsened existing health inequalities, find researchers
The wide inequalities in Covid-19 vaccine uptake between people from ethnic minority groups and White British people are far greater than for the pre-pandemic flu jab, a study by University of Manchester health researchers has found. The findings, published in PLoS Medicine , overturns the prevailing view that ethnic inequalities in Covid-19 vaccine uptake simply follow previous trends in people's willingness to take up vaccination.