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Results 521 - 540 of 638.


Life Sciences - Pharmacology - 30.04.2019
Offers insight into the proteins in the brain that detect cannabis
Researchers at the University of Bristol have made new progress in understanding how cannabinoid receptors (CB1Rs), the proteins that detect the active components of marijuana, are controlled in the brain. The brain contains about 100 billion nerve cells that are constantly communicating with one another at specialised junctions called synapses.

Health - Pharmacology - 26.04.2019
Imperial launches world’s first Centre for Psychedelics Research
The first formal centre for psychedelic research in the world will launch at Imperial College London today. Funded by more than 3 million from five founding donors, the new Imperial Centre for Psychedelic Research will build on over a decade of pioneering work in this area carried out at Imperial, including a clinical trial that has kick-started global efforts to develop psilocybin therapy into a licensed treatment for depression.

Pharmacology - Health - 25.04.2019
Researchers in international drive to develop safer drugs
Medical researchers at the University of Nottingham and NIHR Nottingham Biomedical Research Centre are part of a major new international research project to improve the safety and regulation in the development of drugs. The team of experts in drug-induced liver injury will be members of the Translational Safety Biomarker Pipeline (TransBioLine) - a pioneering project which will generate data to support the development of novel safety biomarkers for five target organ systems (kidney, liver, pancreas, vascular and central nervous system) for use in drug development.

Pharmacology - Health - 15.04.2019
Statins fail to lower cholesterol in over half of all patients
Experts have warned a more tailored approach is needed to the prescribing of statins, following a new study suggesting they are ineffective at lowering cholesterol to target levels in more than half of patients. The research by primary care experts at The University of Nottingham, which is published in Heart , found that 51.2 per cent of patients prescribed statins saw little benefit to their cholesterol levels within two years, leading to a significant risk of developing cardiovascular disease in the future.

Pharmacology - Health - 12.04.2019
Clinical trials: Important feedback on new cancer treatments from thousands of patients remains unpublished
Macmillan Cancer Support and the University of Birmingham urge researchers to use newly developed international guidelines so that all key data is published and patients are fully informed about how cancer drugs affect quality of life. Important feedback about quality of life from up to 49,000 cancer patients who took part in UK-led clinical trials from 2000-2014 remains unpublished, according to a new study led by researchers at the University of Birmingham and funded by Macmillan Cancer Support.

Health - Pharmacology - 11.04.2019
Bristol part of 20.8M study to drive drug discovery for atopic dermatitis and psoriasis
The lives of patients affected by atopic dermatitis and psoriasis could be improved thanks to the start of an EU-funded research project BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis). The five-year project will address key unmet needs in treating these common inflammatory skin conditions by analysing data from more than 50 000 patients to improve disease understanding, patient care and future therapies.

Pharmacology - Life Sciences - 10.04.2019
Active lifestyles may help nerves to heal after spinal injuries
Leading an active lifestyle may increase the likelihood of damaged nerves regenerating after a spinal cord injury. The early-stage findings , published in the journal Science Translational Medicine , come from studies in mice and rats with spinal cord injuries, in which scientists uncovered a mechanism for nerve fibres repairing after they had been damaged.

Pharmacology - Health - 05.04.2019
New target for development of drugs to fight viruses
Researchers at Cardiff University have discovered that a molecule responsible for guiding virus-killing T-cells to the site of infection is also responsible for rapidly increasing T-cell numbers to fight infection, making it an important new target for the development of more effective drugs to treat both viruses and cancers.

Life Sciences - Pharmacology - 04.04.2019
Scientists fine-tune signalling pathways to tweak responses to stimuli in yeast
Imperial academics have streamlined a signalling pathway in yeast to understand how cell sensing can be tuned by changing protein levels. The research , published in Cell , could eventually help us understand drug side effects in humans, and has immediate implications for biotechnology research. G-protein coupled receptors (GPCRs) are proteins which let cells detect chemical substances like hormones, poisons, and drugs in their environment.

Pharmacology - Life Sciences - 26.03.2019
New ’pulsing’ ultrasound technique improves drug delivery to brains of mice
Using rapid short-pulse sequences of ultrasound helps drugs reach the brains of mice, according to new Imperial College London research. Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. Now, these new findings from Imperial on shorter-wave pulses could change how drugs are used to help patients of Alzheimer's and other neurological diseases.

Pharmacology - Health - 23.03.2019
Levothyroxine treatment in women with thyroid antibodies may not increase live birth rate
It was unclear from previous evidence whether treating women with normal thyroid function and with thyroid peroxidase antibodies with Levothyroxine would improve live-birth rates Treating women with thyroid antibodies but a normal thyroid function with a medicine called Levothyroxine does not make them more likely to deliver a live baby, new research led by the University of Birmingham suggests.

Health - Pharmacology - 22.03.2019
Bringing a new generation of drugs to patients
Cardiff University is stepping up the development of new drugs for mental health and central nervous system conditions, with the launch of the Medicines Discovery Institute. Focusing on areas of unmet clinical need, the new institute will develop novel medications to improve the lives of people across the world.

Pharmacology - Health - 18.03.2019
Caterpillars could hold the secret to new treatment for Osteoarthritis
A substance from a fungus that infects caterpillars could offer new treatment hope for sufferers of osteoarthritis according to new research. Cordycepin is an active compound isolated from the caterpillar fungus Cordyceps militaris and has proved to be effective in treating osteoarthritis by blocking inflammation in a new way, through reducing a process called polyadenylation.

Pharmacology - Health - 13.03.2019
New cholesterol-lowering drug could help patients unable to take statins
A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid, an oral medication - yet to be approved in Europe - which inhibits the body's ability to create the building blocks of cholesterol.

Pharmacology - Health - 13.03.2019
Molecular patterns could better predict breast cancer recurrence
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a study published in Nature.

Pharmacology - Health - 07.03.2019
Potential new treatment for heart attack
Scientists have found a potential new drug for treating the heart damage caused by a heart attack - by targeting the way the heart reacts to stress. This is the finding of new research, by scientists at Imperial College London and published in the journal Cell Stem Cell. There are no existing therapies that directly address the problem of muscle cell death Professor Michael Schneider Study author The research team, part-funded by the British Heart Foundation (BHF) used stem cells to grow heart tissue and mimic a 'heart attack in a dish'.

Health - Pharmacology - 06.03.2019
New Hepatitis C cases down by almost 70 per cent in HIV positive men in London
New cases of hepatitis C amongst HIV positive men in London have fallen by nearly 70 per cent in recent years. The new analysis of data from three clinics in London found 256 men were diagnosed between 2013-2018. New infections peaked at 17 for every 1000 people studied in 2015 and fell to six by 2018.

Pharmacology - Health - 05.03.2019
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, reports a paper led by UCL and Imperial College London. The case report comes ten years after the first such case, known as the 'Berlin Patient.' Both patients were treated with stem cell transplants from donors carrying a genetic mutation that prevents expression of an HIV receptor CCR5.

Life Sciences - Pharmacology - 05.03.2019
Could genetic breakthrough finally help take the sting out of mouth ulcers?
A large breakthrough has been made in the genetic understanding of mouth ulcers which could provide potential for a new drug to prevent or heal the painful lesions. Mouth ulcers affect up to 25 per cent of young adults and a higher proportion of children. Previous research has shown that mouth ulcers are partially heritable, but until now there has been little evidence linking specific genes or genomic regions to mouth ulcers.

Pharmacology - Health - 05.03.2019
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, according to a study published today in Nature.