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Health - Pharmacology - 02.09.2020
Combining PCR and antibody tests at point of care dramatically increases COVID-19 detection in hospitalised patients
A Cambridge hospital has piloted the use of combined rapid point-of-care nucleic acid and antibody testing for SARS-CoV-2 infection after researchers at the University of Cambridge showed that this approach was superior to virus detection alone for diagnosing COVID-19 disease. PCR and antibody tests both have limitations because of the nature of coronavirus infection and how our body responds.

Health - Pharmacology - 31.08.2020
Implant choice more important than surgeon skill for hip replacement success
A study analysing over 650,000 hip replacement patients across England and Wales over 14 years sought to investigate why one hospital has consistently been identified as having better than expected outcomes compared to other settings. The findings have shown that the outstanding hip implant survival results seen in one centre in the UK are associated with implant choice more than surgeon skill.

Pharmacology - Health - 25.08.2020
Better drug treatment for miscarriage as patients struggle to access surgery in Covid-19 pandemic
The trial found that the combined drug treatment worked in 83% of cases, compared to 76% in the placebo group - and crucially, it reduced the need for surgery. A new drug combination is more effective for women having miscarriages without symptoms than current standard NHS treatment, according to an NIHR funded study from Tommy's National Centre for Miscarriage Research published today in The Lancet.

Health - Pharmacology - 24.08.2020
Using hydroxychloroquine with common antibiotic increases cardiovascular risk
The combination of hydroxychloroquine and azithromycin has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed comparing hydroxychloroquine treatment to hydroxychloroquine and azithromycin treatment for rheumatoid arthritis patients. Hydroxychloroquine is commonly used to treat rheumatoid arthritis, while azithromycin is a frequently-prescribed antibiotic to treat infections such as pneumonia, chest and sinus infections, etc.

Health - Pharmacology - 24.08.2020
Clinical research reduced by 87 per cent at peak of pandemic
At the peak of the COVID-19 pandemic, clinical research capacity may have been reduced by up to 87% in England, finds a new study led by UCL academics.

Pharmacology - Health - 19.08.2020
Breakthrough research breathes hope into a new treatment for asthma
An international team of scientists, led by the University of Glasgow, has announced findings that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD). The breakthrough findings, published today in Science Translational Medicine , identify a new class of drugs that reverse the symptoms of asthma in animal models.

Pharmacology - 17.08.2020
Targeted treatment for depression could benefit patients with psychosis
Patients with early onset psychosis may benefit from treatment for depression, including with anti-depressants alongside other medication, new research shows. According to scientists at the University of Birmingham's Institute for Mental Health , depression may be an intrinsic part of early phase psychotic disorders that should be treated together with other more prominent symptoms to improve patient outcomes.

Health - Pharmacology - 12.08.2020
Meditation-relaxation therapy may offer escape from the terror of sleep paralysis
Sleep paralysis - a condition thought to explain a number of mysterious experiences including alleged cases of alien abduction and demonic night-time visits - could be treated using a technique of meditation-relaxation, suggests a pilot study published today. I know first-hand how terrifying sleep paralysis can be, having experienced it many times myself.

Pharmacology - 11.08.2020
What patients want most from their GP is trust and respect, finds study
Relationships between GPs and patients are changing. It is becoming more difficult for patients to see their preferred GP. In a study by researchers from the University of Bristol's Centre for Academic Primary Care, patients reported that, regardless of whether they were able to see the same GP or not, what they most wanted is to be trusted and respected by their GP.

Pharmacology - Life Sciences - 07.08.2020
A novel strategy for using compounds as ’anti-evolution’ drugs to combat antibiotic resistance
The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance. Researchers at Oxford University have tested this hypothesis by quantifying differences in evolvability between pathogen strains and by searching for 'potentiator' genes that accelerate the evolution of resistance.

Health - Pharmacology - 04.08.2020
Immunotherapy biomarker discovery could benefit thousands with Type 1 diabetes
Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively. Type 1 diabetes is an autoimmune disease, which means it is caused by the body's own immune system attacking healthy body tissues.

Health - Pharmacology - 30.07.2020
’Pill on a string’ test to transform oesophageal cancer diagnosis
A 'pill on a string' test can identify ten times more people with Barrett's oesophagus than the usual GP route, after results from a 3-year trial were published in the medical journal  The Lancet . It's taken almost a decade of research and testing thousands of patients to show that we've developed a better route to diagnosing Barrett's oesophagus Rebecca Fitzgerald The test, which can be carried out by a nurse in a GP surgery, is also better at picking up abnormal cells and potentially early-stage cancer.

Pharmacology - Health - 29.07.2020
Prescribed CBD could help people quit cannabis
Cannabidiol (CBD) could be a safe and effective treatment for problematic cannabis use, according to new findings from a benchmark clinical trial involving UCL. The study, published today in The Lancet Psychiatry , was the first-ever randomised clinical trial of CBD, a non-intoxicating constituent part of the cannabis plant, for cannabis use disorder.

Health - Pharmacology - 24.07.2020
Simple urine test could significantly improve detection of adrenal cancer
Over a six-year period, researchers studied more than 2000 patients with newly diagnosed adrenal tumours from 14 centres of the European Network for the Study of Adrenal Tumours (ENSAT) Using a simple urine test alongside routine imaging for patients with adrenal masses could speed up adrenal cancer diagnosis, improving patient's prognosis and reducing the need for invasive diagnostic procedures, a new multi-centre study published in The Lancet Diabetes & Endocrinology has found.

Health - Pharmacology - 23.07.2020
Key to restricting antibiotic resistant bacteria | University of Oxford
Antibiotic resistance poses a significant threat to human health on a global scale. It has been predicted that resistant infections will cause 10 million deaths per year by 2050. Given that antibiotics are crucial in many areas of medicine, it is important to understand how antibiotic use influences the likelihood that resistance will emerge in response to treatment.  Researchers from the 's Department of Zoology have discovered that moderate doses of antibiotics restrict the emergence of antibiotic-resistant bacteria.

Life Sciences - Pharmacology - 22.07.2020
Antibiotics disrupt development of the ’social brain’ in mice
Antibiotic treatment in early life seems to impede brain signalling pathways that function in social behaviour and pain regulation in mice, a new study by Dr Katerina Johnson and Dr Philip Burnet has found. It was published today in  BMC Neuroscience .  Katerina Johnson, from the University's Departments of Psychiatry and Experimental Psychology, was researching the effects of disrupting the microbiome on the brain in mice.

Health - Pharmacology - 22.07.2020
COVID-19 patients admitted from more deprived regions are at higher risk of intensive care admission
69.9% of BAME patients included in the study were populated within areas of high living environment deprivation compared to 50.2% of White patients. Black, Asian minority ethnic patients with COVID-19 are more likely to be admitted to hospital from regions with higher levels of air pollution, lower quality housing and overcrowded living conditions and are more likely to be admitted to intensive care, a new UK study has found.

Health - Pharmacology - 16.07.2020
Flagship Cancer Research UK precision medicine trial highlights the need for a new approach in treating genomically complicated cancers
Since the trial opened to recruitment in May 2015 until November 2019, 288 patients have been recruited to the 19 targeted treatment cohorts on the trial. A pioneering lung cancer study, led by the University of Birmingham's Cancer Research UK Clinical Trials Unit , has highlighted important factors that will need to be considered in the next wave of precision medicine studies particularly in treating genomically complicated cancers.

Health - Pharmacology - 16.07.2020
Discovery of new immune targets inside flu virus offers hope for universal vaccine
New markers hidden inside the influenza virus have been discovered by scientists at Cardiff University. The researchers from the School of Medicine worked with an international team of experts - including collaborators in Moscow, Russia and Melbourne, Australia - to look at how people's immune systems responded to the new protein markers.

Health - Pharmacology - 15.07.2020
Overall COVID-19 intensive care mortality has fallen by a third
The review , led by the University of Bristol and Royal United Hospitals Bath NHS Trust published today in Anaesthesia, a journal of the Association of Anaesthetists, also shows ICU mortality for the disease is similar across the three continents included: Europe, Asia and North America. "The important message is that as the pandemic has progressed and various factors combine, survival of patients admitted to ICU has significantly improved.
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