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Health - Pharmacology - 09.06.2023
Global study highlights deaths of newborn babies from sepsis
Global study highlights deaths of newborn babies from sepsis
A global observational study co-led by UCL, which involved more than 3,200 newborn babies suffering from sepsis in 19 hospitals in 11 countries, has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness. The study, conducted from 2018 to 2020, found there was high mortality among infants with culture-positive* sepsis (almost 1 in 5 across the hospital sites), and a significant burden of antibiotic resistance.

Pharmacology - Health - 05.06.2023
Promising novel treatment for Osteoarthritis revealed by new research
The University of Manchester and Link Biologics Limited today announced the publication of preclinical data on a potential new treatment for Osteoarthritis in the peer-reviewed journal, Osteoarthritis and Cartilage. This paper describes the development of a protein biological drug termed Link_TSG6 with disease modifying properties.

Health - Pharmacology - 02.06.2023
Multi-cancer blood test shows real promise in NHS trial
An NHS trial of a new blood test for more than 50 types of cancer correctly revealed two out of every three cancers in more than 5,000 people who had visited their GP with suspected symptoms, in England or Wales. The test also correctly identified the original site of cancer in 85% of those cases. The SYMPLIFY study is the first large-scale evaluation of a multi-cancer early detection (MCED) test in individuals who presented to their GP for diagnostic follow-up for suspected cancer.

Health - Pharmacology - 01.06.2023
Prisoner healthcare puts patients at risk
Prisoner healthcare puts patients at risk
The healthcare needs of prisoners in England are not being met and essential changes are needed to ensure patient safety, according to new research led by Cardiff University. The first nationwide analysis of patient safety in prisons in England found that prisoners are experiencing delayed access to healthcare services and medication-related harm.

Health - Pharmacology - 30.05.2023
Wirelessly-powered ’smart bandage’ could provide drug-free wound care
A new generation of wirelessly-powered, environmentally-friendly 'smart bandages' could help patients with non-healing wounds avoid infections, scientists say. The bandage could help improve the quality of life of people who live with chronic non-healing wounds, which currently frequently require painful cleaning and treatment.

Health - Pharmacology - 25.05.2023
Five types of heart failure identified using AI tools
Five types of heart failure identified using AI tools
Five subtypes of heart failure that could potentially be used to predict future risk for individual patients have been identified in a new study led by UCL researchers. Heart failure is an umbrella term for when the heart is unable to pump blood around the body properly. Current ways of classifying heart failure do not accurately predict how the disease is likely to progress.

Health - Pharmacology - 24.05.2023
Anticoagulation treatment after an ischemic stroke should be started earlier
An international clinical trial, which involved experts from Glasgow, has concluded that anticoagulation treatment could be safely started earlier than current recommended guidelines in patients following ischemic stroke with atrial fibrillation. The study - published in the New England Journal of Medicine and led by the led by the Stroke Center, Inselspital, University Hospital Bern, and the University of Bern - found the chances of suffering a recurrent event with earlier treatment were likely to be lower compared to a later start, without an increase in risk of complications.

Health - Pharmacology - 19.05.2023
The safety of GP prescribing in England was not adversely affected by the Covid-19 pandemic
The safety of GP prescribing in England was not adversely affected by the Covid-19 pandemic
Researchers from the universities of Oxford and Nottingham have found that despite substantial disruption to primary care services, the safety of GP prescribing in England was largely unaffected by the Covid-19 pandemic. The study, published in BMJ Medicine , is the most comprehensive assessment of medication safety during the Covid-19 pandemic in England, covering 95% of the population.

Health - Pharmacology - 18.05.2023
New ’microwave’ medical treatment shows promise for patients with HPV
An innovative new medical device which uses microwave heating has shown promising potential for treating precancers and cancers caused by infection with human papillomavirus (HPV). The results - led by the MRC-University of Glasgow Centre for Virus Research (CVR) and published in Lancet eBioMedicine - used 3D 'living skin' in laboratory models of HPV-infected tissues and found that microwave treatment resulted in precise, localised cell death in these tissues without damaging the surrounding areas.

Pharmacology - Health - 17.05.2023
Non-antibiotic treatment for women with persistent acne shown to be effective
A team of researchers led by the University of Southampton has shown that a cheap and readily available drug, used to treat high blood pressure, could help the thousands of women who suffer from persistent acne. The SAFA study, funded by the National Institute for Health and Care Research (NIHR), is the first large-scale clinical trial to provide evidence that spironolactone is an effective treatment for the skin condition.

Pharmacology - Health - 17.05.2023
Patients with rheumatic and musculoskeletal conditions vulnerable to long term opioid use
Up to 1 in 3 with rheumatoid arthritis or fibromyalgia starting an opioid for the first time may be at risk, warn researchers Patients with rheumatic and musculoskeletal conditions are vulnerable to long term opioid use, with up to 1 in 3 of those with rheumatoid arthritis or fibromyalgia potentially at risk, suggest researchers at The University of Manchester The findings, published in the Annals of the Rheumatic Diseases show people with rheum

Health - Pharmacology - 11.05.2023
Obesity accelerates loss of COVID-19 vaccination immunity
Obesity accelerates loss of COVID-19 vaccination immunity
The protection offered by COVID-19 vaccination declines more rapidly in people with severe obesity than in those with normal weight, scientists at the Universities of Cambridge and Edinburgh have found. The study suggests that people with obesity are likely to need more frequent booster doses to maintain their immunity.

Pharmacology - Health - 10.05.2023
Most antidepressants prescribed for chronic pain lack reliable evidence of efficacy or safety, scientists warn
Most antidepressants prescribed for chronic pain lack reliable evidence of efficacy or safety, scientists warn
Most antidepressants used for chronic pain are being prescribed with "insufficient" evidence of their effectiveness, scientists have warned. A major investigation into medications used to manage long-term pain found that harms of many of the commonly recommended drugs have not been well studied. The Cochrane review, led by scientists from several UK universities including Southampton and Newcastle, examined 176 trials consisting of nearly 30,000 patients involved in assessments which prescribed antidepressants for chronic pain.

Health - Pharmacology - 05.05.2023
Genetic clues could predict leukaemia patients' risk of treatment failure
Genetic clues could predict leukaemia patients’ risk of treatment failure
New research led by UCL and Great Ormond Street Hospital (GOSH) to predict which childhood leukaemia patients are at higher risk of not responding well to chemotherapy will allow clinicians to refine treatment strategies to give the best chance of success. The study, published in the Journal of Clinical Oncology , combined UK trial data from 2003-2019 to see which patients had worse outcomes.

Health - Pharmacology - 04.05.2023
Q&A: Does diabetes mean worse outcomes for cancer patients?
Diabetes is a known risk factor for developing cancer, but could it also predict how cancer patients respond to treatment? In a recent study of thousands of cancer patients*, researchers found that having Type 2 diabetes was strongly linked to worse outcomes among those receiving immunotherapy drugs called immune checkpoint inhibitors.

Health - Pharmacology - 03.05.2023
Southampton bone disease study praised by MP Caroline Nokes
Politician Caroline Nokes MP has praised University of Southampton academics for their pioneering work which found inequalities in both the treatment of men and women with debilitating bone diseases and sex bias in laboratory experiments. The Member of Parliament for Romsey and Southampton North, on visiting the University, heard how medication used for skeletal conditions including osteoporosis has historically been developed with female patients in mind.

Health - Pharmacology - 27.04.2023
Cause of heart damage from cancer drugs identified
Safer cancer drugs are now one step closer after a new study led by UCL researchers found the likely reason that some treatments damage the heart. Modern drugs can be very effective at treating cancer and have led to greatly improved survival rates. However, some cancer treatments can cause damage to the heart, or cardiotoxicity.

Pharmacology - Health - 26.04.2023
Promising results of clinical trial of radiotherapy for patients with mesothelioma announced
Researchers trialing a higher dose of treatment in patients with mesothelioma, as part of the SYSTEMS-2 clinical trial, found a significant increase in life expectancy in the patients who received the higher dose of radiotherapy, according to preliminary results announced at the British Thoracic Oncology Group's (BTOG) annual conference.

Health - Pharmacology - 17.04.2023
Targeting historic infections in DNA could boost cancer treatment
Remnants of ancient retroviruses passed down in our DNA could be an effective target for antibodies against lung cancer, according to a new study by researchers at UCL and the Francis Crick Institute. The research, published in Nature and part-funded by Cancer Research UK, could improve our understanding of why patients respond differently to immunotherapy treatments - allowing the therapies to be improved for the future.

Pharmacology - Health - 17.04.2023
Modified Botox gives long-term pain relief after nerve injury without side effects
A modified form of Botox could give long term pain relief to patients with chronic nerve injury pain, according to a study by scientists from UCL, the Universities of Sheffield and Reading and US-based biopharmaceutical company Neuresta. The researchers have created a new, elongated botulinum neurotoxin which can alleviate chronic pain without risk of paralysis or addiction.
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