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Health - Pharmacology - 23.07.2021
Longer interval between the first and second Pfizer vaccine boosts antibody levels and ’helper’ T cells
A new study carried out in collaboration with the University of Birmingham shows both short and long dosing schedules of the Pfizer COVID-19 vaccine generate strong antibody and T cell immune responses. The study, led by the University of Oxford, in collaboration with the Universities of Birmingham, Newcastle, Liverpool, Sheffield, and supported by the UK Coronavirus Immunology Consortium, is one of the most comprehensive studies into the immune response generated by the Pfizer COVID-19 vaccine to date.

Pharmacology - Health - 23.07.2021
New dietary treatment for epilepsy well tolerated and reduced seizures
New dietary treatment for epilepsy well tolerated and reduced seizures
The first clinical trial of a new dietary treatment for children and adults with severe forms of epilepsy, co-developed by UCL researchers and based on the ketogenic diet, has been successfully completed.

Health - Pharmacology - 23.07.2021
Study highlights ’vital 30-day window’ for hospital inpatients to get COVID-19 jab
A new study published today has highlighted a "30-day window" for hospital inpatients to be vaccinated against COVID-19 to help reduce their risk of dying. A Cardiff University-led team analysed 2,508 hospital patients across 18 sites during the first wave of the pandemic to assess the impact of being infected with COVID-19 in hospital on risk of death.

Health - Pharmacology - 22.07.2021
Llama 'nanobodies' could hold key to preventing deadly post-transplant infection
Llama ’nanobodies’ could hold key to preventing deadly post-transplant infection
Scientists have developed a 'nanobody' - a small fragment of a llama antibody - that is capable of chasing out human cytomegalovirus (HCMV) as it hides away from the immune system. This then enables immune cells to seek out and destroy this potentially deadly virus. Our team has shown that nanobodies derived from llamas have the potential to outwit human cytomegalovirus Ian Groves Around four out of five people in the UK are thought to be infected with HCMV, and in developing countries this can be as high as 95%.

Health - Pharmacology - 22.07.2021
Clinical trial of Alzheimer’s drug developed at UCL begins
A clinical trial of a new drug candidate for Alzheimer's disease which has been developed at UCL in partnership with the pharmaceutical company Eisai has begun at UCLH with participants now being screened. Participants in the trial, conducted at the UCLH Leonard Wolfson Experimental Neurology Centre (NIHR UCLH Clinical Research Facility), will have the rare inherited form of Alzheimer's disease.

Health - Pharmacology - 19.07.2021
Biological 'fingerprints' of long COVID in blood could lead to diagnostic test, say Cambridge scientists
Biological ’fingerprints’ of long COVID in blood could lead to diagnostic test, say Cambridge scientists
Markers in our blood - 'fingerprints' of infection - could help identify individuals who have been infected by SARS-CoV-2, the coronavirus that causes COVID-19, several months after infection even if the individual had only mild symptoms or showed no symptoms at all, say Cambridge researchers. Because we currently have no reliable way of diagnosing long COVID, the uncertainty can cause added stress to people who are experiencing potential symptoms.

Pharmacology - Health - 19.07.2021
Study highlights more effective and safe way to deliver chemotherapy
A new study, led by the University of Glasgow and published in The Lancet, has compared the three main ways anticancer treatment is given to patients when administered via a central vein. Hickman-type tunnelled catheters (Hickman), peripherally inserted central catheters (PICCs), and totally implanted ports (PORTs) are used to deliver systemic anticancer treatment (SACT) via a central vein.

Health - Pharmacology - 15.07.2021
Computerised image analysis identifies new subtype of debilitating lung disease
Scientists at UCL have used computer-based imaging analysis to identify new patterns of lung damage in patients with Idiopathic pulmonary fibrosis (IPF), providing the first evidence of a previously unknown and life-limiting lung disease subtype. IPF is a condition where scar tissue or fibrosis builds up in the lungs, making them thick and hard.

Health - Pharmacology - 14.07.2021
Personalised 3D printed knee implant could bring relief to thousands of arthritis sufferers
Personalised 3D printed knee implant could bring relief to thousands of arthritis sufferers
Pioneering 'printed metal' procedure to create bespoke treatment for early knee osteoarthritis set to be trialled in the UK following MHRA approval. Last updated on Thursday 15 July 2021 A groundbreaking new treatment that uses 3D printed implants and that could bring relief to tens of thousands of knee osteoarthritis sufferers has received approval to be trialled in UK patients, following a virtual "in-silico" trial that demonstrated its safety.

Health - Pharmacology - 09.07.2021
Commonalities found between COVID-19 and Rheumatoid Arthritis could help development of new treatment strategies for Long Covid
Severe COVID-19 and Rheumatoid Arthritis (RA) share some common pathogenic mechanisms, according to a new study. The observations from the study - published in JCI Insight and led by the University of Glasgow's Research into Inflammatory Arthritis Centre (RACE) in collaboration with the Fondazione A.Gemelli IRCCS in Italy - could help development of new treatment strategies for severe COVID-19 and post-COVID-19 syndrome, or Long Covid.

Health - Pharmacology - 07.07.2021
Arthritis drugs save lives of hospitalised Covid-19 patients
Drugs used to treat arthritis, known as interleukin-6 antagonists, reduce deaths and the need for mechanical ventilation among people hospitalised with Covid-19, according to a new study involving UCL which has prompted new World Health Organization (WHO) recommendations. In the study, published in the Journal of the American Medical Association , researchers analysed 27 randomised trials involving nearly 11,000 patients.

Health - Pharmacology - 04.07.2021
COVID vaccines: combining AstraZeneca and Pfizer may boost immunity - new study
Late last year, I asked : is it safe to have more than one type of COVID-19 vaccine? A trial has now addressed that question, as well as what effect combining different vaccine types has on immunity. Most COVID-19 vaccines require two doses, and the usual strategy is to give people the same vaccine type for both.

Health - Pharmacology - 02.07.2021
Detecting oesophageal cancer with AI
Detecting oesophageal cancer with AI
Experts at UCL and spinout company Odin Vision working with clinicians at UCLH have used artificial intelligence (AI) to help detect early signs of oesophageal cancer. The first procedure in the world using the AI technology was performed at University College Hospital by UCLH consultant gastroenterologist Dr Rehan Haidry.

Pharmacology - Health - 02.07.2021
Aspirin could cut risk of death in cancer patients by 20%, major review of studies suggests
Patients with a wide range of cancers who take aspirin as part of their treatment could help to reduce their risk of death by 20%, a major review of existing research has suggested. Academics at Cardiff University carried out a systematic review of 118 published observational studies in patients with 18 different cancers.

Pharmacology - Psychology - 01.07.2021
Autistic individuals may be more likely to use recreational drugs to self-medicate their mental health
Autistic individuals may be more likely to use recreational drugs to self-medicate their mental health
While autistic individuals are less likely to use substances, those who do so are more likely to self-medicate for their mental health symptoms, according to new research from the University of Cambridge and published today in The Lancet Psychiatry .

Health - Pharmacology - 30.06.2021
Scientists identify 160 new drugs that could be repurposed against COVID-19
Scientists identify 160 new drugs that could be repurposed against COVID-19
Cambridge scientists have identified 200 approved drugs predicted to work against COVID-19 - of which only 40 are currently being tested in COVID-19 clinical trials. We hope this resource of potential drugs will accelerate the development of new drugs against COVID-19.

Health - Pharmacology - 30.06.2021
Ethnic disparities in statin treatment may lead to more heart attacks and strokes
People of South Asian and African/ African Caribbean ethnicity who have type 2 diabetes are less likely to be prescribed statins than those of European ethnicity, potentially contributing to thousands of preventable heart attacks and strokes each year, finds a new UCL-led study. The study, published in the open access journal PLOS Medicine and funded by Diabetes UK, used a database of 12 million anonymised national health records to look at rates of statin prescribing for people newly diagnosed with type 2 diabetes who were also eligible for statins.

Health - Pharmacology - 30.06.2021
Researchers to investigate new drug to stop incurable prostate cancer spread
Researchers to investigate new drug to stop incurable prostate cancer spread
A team of Cardiff researchers has won major funding of nearly half a million pounds to explore why and how prostate cancer spreads to bone. Prostate cancer is the most commonly diagnosed cancer in the UK - and the second leading cause of death in men - and there is no cure when it spreads to bone. Dr Toby Phesse and Dr Helen Pearson, from the University's European Cancer Stem Cell Research Institute, have received 491,731 from the charity Prostate Cancer Research (PCR) to investigate how a specific cell signalling pathway is controlling the spread of prostate cancer to the bone.

Health - Pharmacology - 24.06.2021
Remote home monitoring models can support COVID-19 patients and reduce demand on hospital services
Remote home monitoring models can support COVID-19 patients and reduce demand on hospital services
A study led by the National Institute for Health Research (NIHR) BRACE and RSET Rapid Evaluation Centres and undertaken by researchers at UCL, Nuffield Trust, RAND Europe and the University of Birmingham suggests that effective coordination between primary and secondary care to set up and deliver remote home monitoring models can help patients and reduce demand on hospital services during the period of COVID-19.

Health - Pharmacology - 24.06.2021
Better access to quality health care could curb antimicrobial resistance in East Africa
A One-Health review in East African countries shows that efforts to address antimicrobial resistance must go hand in hand with improved access to quality health care and antimicrobials. Led by the Universities of Glasgow and Edinburgh, under a joint One Health PhD studentship programme, the review found that improving access to quality healthcare provision, of which antimicrobials are a major component, could help to address the risk of antimicrobial resistance in lowand middle-income countries.
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