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Health - Pharmacology - 15.01.2021
Analysis: We have entered a dangerous new phase of the pandemic
Professor Andrew Hayward (UCL Epidemiology & Health) explains why the new, more infectious, strain of Covid-19 is a cause for concern and suggests what must be done to reduce transmission of the disease. On the last day of 2019 the World Health Organization (WHO) received the first reports of an unusual cluster of pneumonia cases in Wuhan, China.

Health - Pharmacology - 15.01.2021
DNA test can quickly identify pneumonia in patients with severe COVID-19, aiding faster treatment
DNA test can quickly identify pneumonia in patients with severe COVID-19, aiding faster treatment
Researchers have developed a DNA test to quickly identify secondary infections in COVID-19 patients, who have double the risk of developing pneumonia while on ventilation than non-COVID-19 patients. Using this test, we found that patients with COVID-19 were twice as likely to develop secondary pneumonia as other patients in the same intensive care unit Andrew Conway Morris For patients with the most severe forms of COVID-19, mechanical ventilation is often the only way to keep them alive, as doctors use anti-inflammatory therapies to treat their inflamed lungs.

Health - 14.01.2021
A quarter of adults reported drinking more during first lockdown
A quarter of people in the UK reported drinking more than usual during the first lockdown, particularly those who were younger, female and suffering from anxiety, finds a study by UCL researchers. The study, published today in Drug and Alcohol Dependence, surveyed over 30,000 adults about their drinking behaviour during the earliest stage of lockdown between 21 March and 4 April 2020 and found that a third (34.3%) weren't drinking.

Health - Pharmacology - 14.01.2021
COVID-19: Mortality risk increases by 20% when ICUs are full
Patients admitted to very full hospitals have an increased chance of dying which is equivalent to being up to 11 years older, according to a new study co-led by UCL researchers. The study, published as a pre-print* on MedRxiv , analysed data from 4032 patients with COVID-19 who were admitted to Intensive Care Units (ICU) with presumed or confirmed Covid-19 in the first lockdown.

Health - Social Sciences - 14.01.2021
No limit to the benefits of exercise in reducing the risk of cardiovascular disease
A new study led by the University of Oxford on over 90,000 participants shows that there is no upper threshold to the benefits of exercise in reducing the risk of cardiovascular disease - 'every move counts towards better cardiovascular health.' Cardiovascular disease is the leading cause of death globally, claiming around 17.9 million lives each year.

Health - 14.01.2021
Accurate predictions of ovarian cancer outcome possible with new classification system
The new, Oxford-developed method for subtyping ovarian cancer has been validated in a recent collaboration between the University of Oxford and Imperial College London. Dubbed the 'Oxford Classic', researchers have demonstrated that it enables the accurate prediction of patient disease outcome, as well as the development of new targeted cancer therapies.

Life Sciences - Health - 14.01.2021
Following the hops of disordered proteins could lead to future treatments of Alzheimer's disease
Following the hops of disordered proteins could lead to future treatments of Alzheimer’s disease
Study shows how to determine the elusive motions of proteins that remain disordered. The constant motion of amyloid-beta is one of the reasons it's been so difficult to target - it's almost like trying to catch smoke in your hands Michele Vendruscolo Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds.

Health - 14.01.2021
How sure would you want to be that you have coeliac disease before starting a gluten-free diet?
A new survey from researchers at NIHR ARC West and the University of Bristol has been launched to understand how sure people want to be that they-ve got coeliac disease before starting a gluten-free diet. Coeliac disease is when a person's immune response to gluten attacks the tissues in their digestive system.

Health - Life Sciences - 14.01.2021
Different mutations in one gene can cause different types of diseases
Leading cancer experts at the University of Birmingham have solved a long-standing question of how various types of mutations in just one gene cause different types of diseases. A team of scientists at the University's Institute of Cancer and Genomic Sciences , led by Professor Constanze Bonifer, studied a gene known as RUNX1, which is responsible for providing instructions for the development of all blood cells and is frequently mutated in blood cancers.

Health - Environment - 13.01.2021
Early COVID-19 lockdown had less impact on urban air quality than first believed
Early COVID-19 lockdown had less impact on urban air quality than first believed
The first COVID-19 lockdowns led to significant changes in urban air pollution levels in major cities around the world, but the changes were smaller than expected - a new study reveals. After developing new corrections for the impact of weather and seasonal trends, such as reduced NO2 emissions from winter to summer, the researchers evaluated changes in ambient NO2, O3 and fine particle (PM2.5) concentrations arising from lockdown emission changes in 11 global cities: Beijing, Wuhan, Milan, Rome, Madrid, London, Paris, Berlin, New York, Los Angeles and Delhi.

Health - Psychology - 13.01.2021
High insulin levels during childhood a risk for mental health problems later in life
High insulin levels during childhood a risk for mental health problems later in life
Researchers have shown that the link between physical and mental illness is closer than previously thought. Certain changes in physical health, which are detectable in childhood, are linked with the development of mental illness in adulthood.

Health - 13.01.2021
Lockdown compliance improving but low take up of Covid tests ’worrying’
Less than half (43%) of people who developed Covid-19 symptoms say they've requested a test, find UCL researchers as part of the Covid-19 Social Study. Three quarters (75%) of adults aged 60+ who reported experiencing symptoms at least once said they had never requested a test, with just 18% of the same age group saying they requested a test every time they experienced symptoms.

Health - 11.01.2021
Light-carrying chips advance machine learning
New study shows targeting arterial stiffening earlier in a person's lifespan could provide cognitive benefits in older age and may help to delay the onset of dementia. Researchers at the University of Oxford and University College London investigated 542 older adults who received two measurements of aortic stiffness, at 64 years old and 68 years old.

Health - 11.01.2021
COVID-19: Online tool identifies patients at highest risk of deterioration
A new risk-stratification tool which can accurately predict the likelihood of deterioration in adults hospitalised with COVID-19 has been developed by UCL researchers, in collaboration with the UK Coronavirus Clinical Characterisation Consortium (known as ISARIC4C). Researchers say the online tool, made freely available to NHS doctors on Friday 8 January 2021, could support clinicians' decision making - helping to improve patient outcomes and ultimately save lives.

Health - 08.01.2021
International travel key to the introduction and early undetected community transmission of COVID-19 in Scotland
Scientists sequencing virus samples from the first confirmed cases of COVID-19 in Scotland (and through the first wave) have found evidence of community transmission, driven by multiple introductions through international travel, as early as February 2020. In new research had multiple introductions to Scotland in early 2020, mainly from European countries such as Italy and Spain.

Life Sciences - Health - 08.01.2021
Study identifies genetic changes likely to have enabled SARS-CoV-2 to jump from bats to humans
Study identifies genetic changes likely to have enabled SARS-CoV-2 to jump from bats to humans
A new study, involving the University of Cambridge and led by the Pirbright Institute, has identified key genetic changes in SARS-CoV-2 - the virus that causes COVID-19 - that may be responsible for the jump from bats to humans, and established which animals have cellular receptors that allow the virus to enter their cells most effectively.

Health - Chemistry - 08.01.2021
Branching out: DNA discovery could advance degenerative disease treatments
New research on the structure and dynamics of a branched form of DNA called a three-way junction could lead to more effectively targeted treatments for degenerative disorders like Huntington's Disease, scientists say. In a new paper published , chemists from the University of Glasgow show for the first time how three-way DNA junctions undergo unexpected rearrangements in their structure.

Health - Life Sciences - 07.01.2021
Deadly parasites create unique cellular structures to survive
Scientists have solved a key parasitic puzzle, revealing the unique and complex structures toxoplasmosis and malaria parasites make in order to survive in different hosts. The new study, led by the University of Glasgow in collaboration with the University of Stockholm, and published , details how certain parasites can create unique cellular structures to control how they create energy and thus survive in different hosts.

Health - Pharmacology - 06.01.2021
'Virtual biopsies' could replace tissue biopsies in future thanks to technique developed by Cambridge scientists
’Virtual biopsies’ could replace tissue biopsies in future thanks to technique developed by Cambridge scientists
A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for cancer patients to help select the best treatment.

Health - 05.01.2021
Dental experts discover biological imbalance is the reason for link between gum and kidney disease
An imbalance of the body's oxygen producing free radicals and its antioxidant cells could be the reason why gum disease and chronic kidney disease affect each other, a new study led by the University of Birmingham has found. Periodontitis - or gum disease - is a common, inflammatory disease which causes bleeding gums, wobbly or drifting teeth and can eventually result in tooth loss.
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