2m boost for study to detect early stage ovarian cancer

NHS Cancer Programme funding will see an advanced test used at GP surgeries in the West Midlands to diagnose early-stage ovarian cancer.

A £2 million study will see an advanced test used at GP surgeries in the West Midlands to diagnose early-stage ovarian cancer - potentially saving thousands of lives a year.

The project involves Sandwell and West Birmingham (SWB) NHS Trust and Walsall Healthcare NHS Trust (WHT) pairing up with primary care provider Modality and the University of Birmingham, to offer a blood test called ROMA to patients experiencing symptoms of ovarian cancer.

Signs of the disease include bloating, stomach pain, needing to wee more often and always feeling full.

If they are persistent, severe, frequent or out of the ordinary women are urged to see their GP where a CA-125 blood test will usually be carried out, which picks up 50 per cent of patients with early-stage cancer.

However, the advanced ROMA test used during this trial at Modality-run GP services in Walsall, Sandwell and West Birmingham, will identify key markers of this particular disease at an earlier stage.

If a patient has tested positive, they will be referred to their local Trust to attend a new one-stop clinic where they’ll see a consultant, undergo a specialist scan and then a further consultation where the results will be shared. They will be referred for further treatment if needed.

Research conducted with my team at the University of Birmingham found out that the ROMA test is significantly better than current tests (CA125 and ultrasound) used in both pre and postmenopausal women.

Professor Sudha Sundar

Speaking about the study, called SONATA (tranSforming Ovarian caNcer diAgnostic paThwAys), University of Birmingham Professor Sudha Sundar and consultant in gynaecological cancer surgery at SWB NHS Trust, said:

"Ovarian cancer is rare and there is a need to increase the understanding and awareness of the symptoms associated with it amongst our population and GPs. We know that 90 per cent of women diagnosed with ovarian cancer at stage one will survive, but this drops drastically to 15 per cent if it is picked up during stage four.

"Research conducted with my team at the University of Birmingham found out that the ROMA test is significantly better than current tests (CA125 and ultrasound) used in both pre and postmenopausal women.

"Whilst a previous study had found that the ROMA test detects up to 20 per cent more early-stage cancers than the current test which only picks up 50 per cent of early-stage cancers. We are putting this research into practice by carrying out this trial."

"With Modality-run GP surgeries trialling the ROMA test we will be able to establish if it is acceptable to patients and clinicians. By testing many samples across two large laboraties we will be able to confirm whether the ROMA test has a higher chance of detecting this cancer earlier than the current CA-125 blood test used and whether implementing this across the NHS will be cost-effective.

Transforming ovarian cancer care

Leading on the project, Dr Aamena Salar, medical director for Modality Partnership Community Services, said: ’Our aspiration is to transform the care of ovarian cancer by earlier detection and better outcomes for our patients."

Nina Jhita, programme director at Modality, added: "This is true innovation; we (primary care) are delighted to collaborate with key system partners across the West Midlands to really make a difference to the lives of women whilst demonstrating how this solution can be scaled across the UK."

The final part of the study will see 41,000 primary care samples sent to the Black Country Pathology Service and South Tyne and Wear laboratories to accurately establish whether using the ROMA test rather than CA125 will be cost effective for the NHS. The results from the study, funded by the NHS Cancer Programme and the Small Business Research Initiative, will be analysed and used to change the way this cancer is diagnosed in the future.

Professor Sundar said:

"Both NHS Trusts will be working with Modality in partnership to see patients testing positive at these newly established one stop clinics with specialist scans to assess and treat them accordingly. The project will run for 18 months and will also involve pathology services analysing the results."

"It’s an exciting study which is a great example of integrated working between all the organisations involved. We are looking forward to finding out the results so that we can change the way this cancer is detected in the future and drastically improve survival rates."

The University of Birmingham is ranked amongst the world’s top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 6,500 international students from over 150 countries.

The University of Birmingham is a founding member of Birmingham Health Partners (BHP), a strategic alliance which transcends organisational boundaries to rapidly translate healthcare research findings into new diagnostics, drugs and devices for patients. Birmingham Health Partners is a strategic alliance between seven organisations who collaborate to bring healthcare innovations through to clinical application:
  • University of Birmingham
  • University Hospitals Birmingham NHS Foundation Trust
  • Birmingham Women’s and Children’s Hospitals NHS Foundation Trust
  • Aston University
  • The Royal Orthopaedic Hospital NHS Foundation Trust
  • Sandwell and West Birmingham Hospitals NHS Trust
  • West Midlands Academic Health Science Network
  • Birmingham and Solihull Mental Health NHS Foundation Trust

The views expressed in the publication are those of the author(s) and not necessarily those of the NHS Cancer Programme or its stakeholders.