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Life Sciences - Pharmacology - 19.10.2021
Largest ever global study of tuberculosis identifies genetic causes of drug resistance
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M. tuberculosis samples from across the world consisting of 15,211 samples from 27 countries on five continents.

Health - Pharmacology - 06.10.2021
Implantable tech could be a game-changer for heart patients
Implantable heart technology is being used in Manchester to assess when a patient is at high risk of dying, thanks to University of Manchester and Manchester University NHS Foundation Trust -led research. The implantable pacemakers and defibrillators contain multiple sensors that allow continuous monitoring of a patient's heart health, 24 hours a day.

Health - Pharmacology - 06.10.2021
Video games can have similar health benefits to jogging
Video games can have similar health benefits to jogging
Active video games could be a motivating way for Type 1 diabetics to keep active and help manage their condition. Last updated on Wednesday 6 October 2021 Active video games have similar positive health effects on the body as traditional exercises, such as jogging on a treadmill, according to a new study.

Pharmacology - Health - 05.10.2021
Campaign could reduce risk of UK opioid ’epidemic’
A campaign that urged GPs to 'think-twice' before putting a patient on opioid medicines is effective in reducing opioid prescribing in primary care, according to the findings of a major study by researchers from the University of Leeds, the University of Manchester and NHS Bradford Districts Clinical Commissioning Group, West Yorkshire.

Pharmacology - Health - 30.09.2021
Staying on long-term antidepressants reduces risk of relapse
When people stop taking antidepressants after a long period of use, just over half (56%) experience a relapse within a year, compared to 39% of those who stay on medication, finds a new study led by UCL researchers. The researchers say their findings, published in The New England Journal of Medicine , can help doctors and patients to make an informed decision together on whether or not to stop their antidepressants after recovery from a depressive episode.

Health - Pharmacology - 29.09.2021
New cancer ’inhibitor’ could lead to improved treatment options
Researchers have discovered a potential advancement in the treatment of chronic myeloid leukaemia (CML), which they hope will one day offer an improved option for treating patients with this form of blood cancer. The study- published today in Science Translational Medicine and led by the University of Glasgow in collaboration with LifeArc - has discovered a potential 'autophagy inhibitor' which, when used in combination with current cancer therapies, could lead to better treatment options for CML cancer patients.

Chemistry - Pharmacology - 24.09.2021
Assembly theory could spell good news for drug discovery
A new method of exploring chemical space could help create scientific breakthroughs in areas including drug design and discovery, its creators say. The concept, known as assembly theory, is outlined in a new paper published today Advances by a team from the University of Glasgow's School of Chemistry.

Health - Pharmacology - 22.09.2021
Setting global targets could cut impact of diabetes in developing countries
Setting global targets could cut impact of diabetes in developing countries
Setting and achieving targets for treating diabetes patients with cholesterol or blood pressure medication, as well as tackling blood sugar levels, could save lives and reduce healthy-lifetime lost due to diabetes in developing countries, a new global study reveals. Some 80% of people with diabetes live in Lowand Middle-income Countries (LMICs).

Health - Pharmacology - 21.09.2021
Pioneering EEG test could dramatically increase early diagnosis of Alzheimer's
Pioneering EEG test could dramatically increase early diagnosis of Alzheimer’s
A two-minute passive-test that measures people's brain waves in response to a series of images, 'Fastball EEG', could help expand early dementia diagnosis. Last updated on Tuesday 21 September 2021 A simple but revolutionary approach to early Alzheimer's diagnosis is being pioneered by researchers through an initiative that could pave the way for improved outcomes for individuals who develop the disease in the future.

Pharmacology - Health - 20.09.2021
New drug shows promise in slowing growth of bowel cancer
A new drug has shown promise in slowing the regrowth of tumours among some bowel cancer patients, according to new findings of a major trial run by researchers at UCL in collaboration with Oxford, Leeds and Cardiff universities. The results of the FOCUS4-C trial, which was funded by Cancer Research UK, the EME Programme - an MRC/NIHR partnership - and AstraZeneca, will be presented on Saturday (18 September) at the European Society of Medical Oncology and published in the Journal of Clinical Oncology .

Health - Pharmacology - 20.09.2021
New Covid-19 treatment for patients with diabetes shows early promise
A new Covid-19 treatment for people with diabetes has shown promising results in a trial led by UCL researchers. The trial was conducted by St George Street Capital (SGSc) - a medical research charity - with the the goal to find new purposes, where there is a real clinical need, for drugs that have already passed safety checks Professors John Martin (UCL Division of Medicine) and Pete Coffey (UCL Institute of Ophthalmology) founded the charity along with an American philanthropist to trial new medicines four years ago.

Pharmacology - Psychology - 17.09.2021
’Spice’ withdrawal symptoms more severe than cannabis - new study
New research from the Addiction and Mental Health Group at the University of Bath highlights challenges for people trying to give up the drug 'Spice'. Last updated on Friday 17 September 2021 Research published today by psychologists at the University of Bath suggests that 'Spice' - which contains synthetic drugs originally designed to mimic the effects of cannabis - is more harmful than cannabis and that users are likely to experience more severe withdrawal symptoms when attempting to quit.

Health - Pharmacology - 16.09.2021
Research provides new insight into fundamental workings of the immune system in response to therapy to treat skin cancer
New research led by the University of Birmingham suggests that skin cancer patients could have a better prognosis if their T cells send messages from five specific genes in their immune response to drugs given to treat the disease. The research, carried out in mice, cells in the laboratory, and using publicly available data from patients with advanced melanoma before and after treatment with Nivolumab therapy, publishes today in Immunity.

Pharmacology - Health - 15.09.2021
Potential new drug for incurable vascular dementia
A drug already used to treat high blood pressure could be re-purposed as the first treatment to tackle a type of vascular dementia caused by damaged and 'leaky' small blood vessels in the brain, according to research part-funded by the British Heart Foundation and published today in the Journal of Clinical Investigation .

Health - Pharmacology - 15.09.2021
COVID vaccine effects wane over time but still prevent death and severe illness
PIC SNIPE/Shutterstock Sheena Cruickshank , University of Manchester Several countries - including the UK - are now offering third COVID-19 shots amid reports of vaccines proving less effective over time. But do these countries really need to embark on widespread booster campaigns? Here's what research tells us so far about how vaccines are performing.

Health - Pharmacology - 13.09.2021
New pathway that prevents bowel cancer treatment from working
Leading scientists at the University of Birmingham have discovered a previously unknown pathway that prevents specific drugs from working in patients with bowel cancer. The research findings pave the way for increasing the number of bowel cancer patients who can be successfully treated, say the scientists.

Pharmacology - Health - 09.09.2021
FDA-approved drugs reduced SARS-CoV-2 infection in lab
An in vitro study of drugs already approved by the regulatory authority in the United States to treat a range of conditions, has shown eight of them are also effective in slowing SARS-CoV-2 replication in infected human cells. The team led by University of Manchester scientists used the drugs to treat liver and kidney cells, which are commonly targeted by the virus in patients with severe disease.

Health - Pharmacology - 09.09.2021
Review suggests best ways to treat to reoccurring prostate cancer
The review funded by Cancer Research UK, in which academics at the Universities of Manchester and Leeds, The Christie NHS Foundation Trust and Leeds Teaching Hospitals NHS Trust screened 2,197 articles is published in the journal Frontiers in Oncology this week (9/09/21). Despite advances in radiation treatment for prostate cancer, an established technique, it can reoccur in some patients most often within the prostate gland itself.

Health - Pharmacology - 08.09.2021
Gut bacteria accumulate many common medications and may reduce their effectiveness
Gut bacteria accumulate many common medications and may reduce their effectiveness
Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the medications' effectiveness.

Health - Pharmacology - 08.09.2021
CPAP and oxygen have similar impact on mortality of COVID-19 patients that wouldn’t benefit from intensive care
Unwell COVID-19 patients may be treated just as effectively with oxygen through a mask rather than the sometimes difficult to tolerate therapy known as Continuous Positive Airway Pressure (CPAP), according to a new study. The patients in the study, whose frailty and other medical conditions meant they were unlikely to benefit from invasive mechanical ventilation and intensive care treatment, received treatment with either an oxygen mask or CPAP.
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