Cancer risk from obesity differs for men and women

A new study, led by researchers at the University of Bristol and the International Agency for Research on Cancer (IARC), has revealed that where fat is on our body may lead to different health outcomes for men and women. The research, co-funded by World Cancer Research Fund (WCRF), Cancer Research UK and Diabetes UK, found that having more body fat around your waist is more dangerous for women than it is for men when it comes to risk of developing colorectal cancer (also known as bowel cancer).

This large study, published in BMC Medicine today [17 December], included over 100,000* people. They found that a higher BMI (body mass index; a measure of total fat) is more dangerous for men, whereas a higher waist-to-hip ratio (your waist circumference divided by your hip circumference; a measure of abdominal fat) is more dangerous for women. To discover this, they used an approach, called Mendelian randomisation, that uses genetic information as a proxy measure for weight to investigate the effect of different body fat measures on colorectal cancer risk in men and women.

An increase in BMI of about five kg/m2 raised the risk of colorectal cancer by 23 per cent for men, but only nine per cent for women. Whereas an equivalent increase in waist-to-hip ratio raised the risk for women by 25 per cent, this was only five per cent for men. Colorectal cancer is the fourth most common cancer in the UK but the second deadliest1, yet it is one of the most preventable cancers by eating a balanced diet, being active and maintaining a healthy weight.

Dr Emma Vincent , Research Fellow in the Bristol Medical School: Populational Health Sciences (PHS) and one of the researchers who led the study, said: "Our study, which is the largest to look at the difference between body fat and colorectal cancer risk in men and women, reveals the need for a more nuanced approach when trying to prevent cancer. We are now working to understand exactly how increased body fat causes colorectal cancer, which may give us new targets for reducing risk. This is important because maintaining weight loss is still very difficult."

Dr Anna Diaz Font, Head of Research funding at WCRF , said: "We know that being overweight or obese increases the risk of at least 12 different types of cancer, including colorectal cancer. But this new research reinforces how important it is to include a wide and diverse range of people in research studies, as we don’t yet fully know the differences gender or race may play when it comes to risk of cancer."

Natasha Paton, Cancer Research UK ’s health information manager, said: "It’s well established that keeping a healthy weight affects many types of cancer. Most research linking excess weight to cancer uses BMI, but this study adds to the evidence that carrying excess fat around the waist is also important.

"People can reduce their risk of bowel cancer by keeping a healthy weight, eating a diet with lots of fibre and less red and processed meat, drinking less alcohol, and not smoking. Diagnosing bowel cancer early saves lives, so if you notice any changes that aren’t normal for you tell your doctor. And we’d encourage people to consider taking up bowel cancer screening when invited."

More research is needed to help understand why this difference between men and women may exist.

* 58,221 people with colorectal cancer and 67,694 controls who did not have colorectal cancer.

Paper

’ Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study ’ by Caroline J. Bull, Joshua A. Bell, Emma E. Vincent, Marc J. Gunte et al in BMC Medicine (open access)


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