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Health - Pharmacology - 08.04.2020
New COVID-19 project will use the power of smartphones to search for treatments
Researchers will look for potential new treatments for COVID-19 using the computing power of people's smartphones. Working with Vodafone Foundation, the ‘Corona-AI' project will use the free DreamLab app , which crunches calculations using a smartphone's computing power while its user sleeps. The app has already helped find potential new cancer drugs and is now aiming to help in the fight against the coronavirus pandemic.

Health - Pharmacology - 03.04.2020
Scientists switch from cancer research to help develop coronavirus vaccine
Scientists switch from cancer research to help develop coronavirus vaccine
A team of Cardiff University scientists has switched from researching cancer to work that could help towards a vaccine for coronavirus. The team at the School of Medicine usually work on reprogramming viruses so they can target and kill cancer - but are now focusing their efforts to help in the fight against the new virus which is gripping the world.

Pharmacology - Health - 02.04.2020
Researchers lead trial to test remdesivir drug on COVID-19 patients
Patients with severe COVID-19 are being recruited to test the drug remdesivir as part of a new trial which is being led by the MRC Clinical Trials Unit at UCL. The trial is the first academic study of the drug as a treatment for coronavirus to take place in the UK The Adaptive COVID-19 Treatment Trial (ACTT-EU/UK) trial, which is taking place in about 75 hospitals globally, recruited its first UK patient this week.

Health - Pharmacology - 01.04.2020
New blood test can detect wide range of cancers
New blood test can detect wide range of cancers
A new blood test that can detect more than 50 types of cancer with high accuracy has been developed by an international team of researchers co-led by UCL. It is expected that the study , published in Annals of Oncology , will play a key role in early detection of cancer, which can often be critical to successful treatment.    The test, developed by GRAIL, looks for tell-tale chemical changes to bits of genetic code - cell-free DNA - that leak from tumours into the bloodstream.

Health - Pharmacology - 27.03.2020
Oxford COVID-19 vaccine programme opens for clinical trial recruitment
Oxford COVID-19 vaccine programme opens for clinical trial recruitment
University of Oxford researchers working in an unprecedented vaccine development effort to prevent COVID-19 have started screening healthy volunteers (aged 18-55) today for their upcoming ChAdOx1 nCoV-19 vaccine trial in the Thames Valley Region. The vaccine based on an adenovirus vaccine vector and the SARS-CoV-2 spike protein is already in production but won't be ready for some weeks still.

Pharmacology - Health - 26.03.2020
’More effective’ stem cell transplant method could aid blood cancer patients
Researchers at UCL have developed a new way to make blood stem cells present in the umbilical cord 'more transplantable', a finding in mice which could improve the treatment of a wide range of blood diseases in children and adults. Blood stem cells, also known as haematopoietic stem cells (HSCs), generate every type of cell in the blood (red cells, white cells and platelets), and are responsible for maintaining blood production throughout life.

Health - Pharmacology - 25.03.2020
New Hepatitis C cases down by almost 70 per cent in HIV positive men
New cases of hepatitis C amongst HIV positive men in London and Brighton have fallen by nearly 70 per cent in recent years. An analysis of five clinics in London and Brighton found that 378 cases were diagnosed between July 2013 - June 2018. New infections peaked at 14 per 1000 people studied in 2015, falling to 4 per 1000 by 2018.

Pharmacology - 24.03.2020
May help older adults stay physically capable for longer
Drug therapies that help older adults maintain their skeletal muscle mass and physical function for longer could be a step closer after researchers at the University of Birmingham identify a key mechanism that drives the clearance of damaged mitochondria. A team in the University's School of Sport, Exercise and Rehabilitation Sciences are well-versed at investigating dynamic machinery within cells called mitochondria.

Pharmacology - Administration - 24.03.2020
Oxford's COVID-19 research receives government funding
Oxford’s COVID-19 research receives government funding
Three Oxford-based COVID-19 projects are among the first to benefit from a share of £20 million in government investment. The three projects include work on an effective vaccine, enabling pre-clinical and clinical vaccine trials, as well as supporting researchers to develop manufacturing processes to produce a vaccine at a million-dose scale. Another project will examine how existing treatments could be repurposed to treat coronavirus.

Health - Pharmacology - 23.03.2020
Fighting coronavirus: Imperial researchers secure funds to help tackle COVID-19
Fighting coronavirus: Imperial researchers secure funds to help tackle COVID-19
Two Imperial research projects are among the first to receive national funding as part of a stream of work to help fight the coronavirus pandemic. In the first round of funding announced by the UK Medical Research Council today, work will begin at the College to develop a potential antibody therapy for COVID-19, as well as clinical project to help to answer some of the key questions about the symptoms and course of the disease.

Pharmacology - Life Sciences - 20.03.2020
In pictures: the Imperial lab developing a COVID-19 vaccine
In pictures: the Imperial lab developing a COVID-19 vaccine
Scores of researchers are racing to create a virus to combat the coronavirus COVID-19. Professor Robin Shattock and his team in Imperial College London's Department of Infectious Disease developed a candidate vaccine within 14 days of getting the sequence from China. They have been testing the vaccine on animals since 10 February and plan to move to clinical trials in the summer.

Health - Pharmacology - 17.03.2020
COVID-19: Imperial researchers model likely impact of public health measures
Researchers from Imperial have analysed the likely impact of multiple public health measures on slowing and suppressing the spread of coronavirus. The latest analysis comes from a team modelling the spread and impact COVID-19 and whose data are informing current UK government policy on the pandemic.

Health - Pharmacology - 16.03.2020
Faecal Microbiota Transplants successfully treat patients with C.diff
A new study from the University of Birmingham has shown that Faecal Microbiota Transplants (FMT) are highly successful in treating patients with Clostridioides difficile (C.diff) infection. Published in EClinical Medicine , results from the first licenced English stool bank, which supplies FMT treatment to patients in the NHS, have shown that in 78% of cases the patient's diarrhoea had stopped and had not returned in the 90 days after treatment.

Pharmacology - Chemistry - 11.03.2020
Bristol pioneers use of VR for designing new drugs
Bristol pioneers use of VR for designing new drugs
The findings, published in the journal PLOS One describe how researchers used VR to understand how common medications work on a molecular level. Many drugs are small molecules, and discovering new drugs involves finding molecules that bind to biological targets like proteins. In the study, users were able to use VR to ‘step inside' proteins and manipulate them, and the drugs binding to them, in atomic detail, using interactive molecular dynamics simulations in VR (iMD-VR).

Health - Pharmacology - 11.03.2020
Possible breast cancer treatment could go to clinical trial immediately as scientists spot target in 'normal' cells
Possible breast cancer treatment could go to clinical trial immediately as scientists spot target in ’normal’ cells
A worldwide collaborative study led by scientists at the University of Sussex has proposed a new treatment strategy for patients with a rare but aggressive subtype of cancer known as triple negative breast cancer. The treatment targets healthy cells using drugs that are already available and currently in use for patients with leukaemia and lymphoma.

Health - Pharmacology - 10.03.2020
Prostate cancer ’fingerprint’ detected in blood sample
Scientists at UCL have invented a new test to identify the earliest genetic changes of prostate cancer in blood: a process which could allow doctors to see if cancers have spread, monitor tumour behaviour and enable better treatment selection. In the study, published in The Journal of Clinical Investigation, researchers at UCL Cancer Institute used Next Generation Sequencing (NGS) to establish if they could identify prostate cancer DNA in blood plasma.

Health - Pharmacology - 09.03.2020
Individual response to COVID-19 ’as important’ as government action
How individuals respond to government advice on preventing the spread of COVID-19 will be at least as important, if not more important, than government action, according to a new commentary from researchers at the University of Oxford and Imperial College London in the UK, and Utrecht University and the National Institute for Public Health and the Environment in the Netherlands.

Life Sciences - Pharmacology - 04.03.2020
Mouse trial shows gene therapy potential for treating childhood brain disorder
Mouse trial shows gene therapy potential for treating childhood brain disorder
Researchers have developed a gene therapy with potential for treating a debilitating childhood neurological condition. The approach, which has only been trialled so far in mice and human cells, is thought to be the first to successfully target a rare genetic condition called CDKL5 deficiency disorder.

Health - Pharmacology - 26.02.2020
Gene therapy shows promise in tackling common cause of childhood blindness
Gene therapy shows promise in tackling common cause of childhood blindness
The results of a first-in-human clinical trial of gene therapy to treat a common cause of genetic blindness have shown partial reversal of sight loss in some patients. X-linked retinitis pigmentosa, caused by mutations in RPGR gene, is the most common cause of blindness in young people. The inherited mutations lead to degeneration of light sensitive cells (photoreceptors) beginning in early childhood leading to severe sight loss.  Until now there has been no treatment for this disease.

Pharmacology - Health - 25.02.2020
Engaging with schizophrenia - experts argue for new approaches to treatment
A better understanding of the lived experience of people with schizophrenia would enable clinicians to help patients live with their condition, alongside treating symptoms with medication and psychotherapy, say experts at the University of Birmingham. According to researchers at the University, this approach would involve developing an understanding of ‘self-disturbance' in schizophrenia - in which patients' sense of connection to themselves and to their actions is disrupted.
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