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Health - Life Sciences - 17.11.2017
Improved method of engineering T-cells to attack cancer
Researchers at Cardiff University have found a way to boost the cancer-destroying ability of the immune system's T-cells, offering new hope in the fight against a wide range of cancers. Using CRISPR genome editing, the team took the genetic engineering of killer T-cells one step further by removing their non-cancer specific receptors and replacing them with ones that would recognise specific cancer cells and destroy them.

Health - 16.11.2017
Prototype ear plug sensor could improve monitoring of vital signs
Scientists have developed a sensor that fits in the ear, with the aim of monitoring the heart, brain and lungs functions for health and fitness. In previous pilot studies that involved trialling the device with 24 people, the researchers from Imperial College London have demonstrated the prototype's potential for monitoring brain, heart and breathing activity.

Health - Psychology - 16.11.2017
Teenage depression linked to father’s depression
Adolescents whose fathers have depressive symptoms are more likely to experience symptoms of depression themselves, finds a new study led by UCL researchers. While the link between mothers' depression and depression in their children is well-established, the new Lancet Psychiatry study is the first to find an association between depression in fathers and their teenaged children, independent of whether the mother has depression, in a large sample in the general population.

Health - Life Sciences - 16.11.2017
’Mini liver tumours’ created in a dish for the first time
Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published , the tiny laboratory models of tumours were used to identify a new drug that could potentially treat certain types of liver cancer. Primary liver cancer is the second most lethal cancer worldwide.

Health - Life Sciences - 15.11.2017
Raising ’good’ cholesterol fails to protect against heart disease
Raising so-called 'good' cholesterol by blocking a key protein involved in its metabolism does not protect against heart disease or stroke, according to a large genetic study of 150,000 Chinese adults published in the journal JAMA Cardiology. There are two types of cholesterol in the blood: LDL-C, so-called 'bad' cholesterol, which is carried in low-density lipoproteins (LDL), and HDL-C, so-called 'good' cholesterol which is found in high-density lipoproteins (HDL).

Life Sciences - Health - 15.11.2017
Signalling protein found to drive heart scarring and organ failure
A part of the immune system once thought to prevent organ damage is actually a leading cause of scarring and heart failure, a study has found. Researchers at Imperial College London discovered that a protein called interleukin 11 (IL-11) plays a key role in the scarring process, which in turn causes heart, kidney and liver failure.

Health - 15.11.2017
Good glucose control could be bad in type 2 diabetes
The common approach of intensive glucose control to achieve low blood sugar targets in type 2 diabetes can increase the risk of mortality, finds a study by Cardiff University. Looking at routine data from over 300,000 people in the UK, collected between 2004 and 2015, researchers found that lower levels of glycated haemoglobin—typically regarded as being good diabetes control—were associated with increased mortality risk, compared to moderate levels, especially in conjunction with intensive treatments that could cause hypoglycaemia.

Health - Life Sciences - 15.11.2017
Improving clinical trials with machine learning
Machine learning could improve our ability to determine whether a new drug works in the brain, potentially enabling researchers to detect drug effects that would be missed entirely by conventional statistical tests, finds a new UCL study published today in Brain . "Current statistical models are too simple.

Life Sciences - Health - 14.11.2017
Antibiotic Discovery in the Abyss
Combining the innovations of synthetic biology with robotic environmental sampling, a team of University of Bristol researchers are travelling to some of the most 'extreme' environments on Earth, including Atlantic depths of 4.5km, to find new leads which could help in the global fight against antimicrobial resistance.

Health - 14.11.2017
Targeting cancer without destroying healthy T-cells
A unique approach to targeting the abnormal T-cells that cause T-cell lymphomas could offer hope to patients with the aggressive and difficult-to-treat family of cancers, finds a study involving researchers from Cardiff University. The team of researchers, working with biopharmaceutical company Autolus Ltd, have discovered a method of targeting the cancer without destroying healthy T-cells, essential to the immune system.

Health - 13.11.2017
Breastfed babies are less likely to have eczema as teenagers, study shows
Babies whose mothers had received support to breastfeed exclusively for a sustained period from birth have a 54 per cent lower risk of eczema at the age of 16, a new study led by researchers from King's College London, Harvard University, University of Bristol and McGill University shows.

Health - 13.11.2017
Breastfed babies are less likely to have eczema as teenagers, study shows
Babies whose mothers had received support to breastfeed exclusively for a sustained period from birth have a 54% lower risk of eczema at the age of 16, a new study led by researchers from King's College London, Harvard University, University of Bristol and McGill University shows.

Pharmacology - Health - 13.11.2017
Philip Leverhulme success for University of Birmingham academics
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer's disease, research led by the University of Birmingham has discovered. Using an electroencephalogram (EEG) - a test that detects electrical activity in a person's brain via electrodes attached to their scalp - researchers studied the brain activity of a group of 25 patients to establish how quickly they processed words shown to them on a computer screen.

Health - Social Sciences - 13.11.2017
Society’s excluded people ten times more likely to die early
People excluded from mainstream society in high-income countries have a tenfold increased risk of early death, according to research from UCL, homeless health charity Pathway and an international team of experts. The researchers found the mortality rate among socially excluded groups including homeless people, people who sell sex, prisoners and people who use hard drugs, was nearly eight times higher than the population average for men, and nearly 12 times for women.

Health - Pharmacology - 13.11.2017
New mechanisms that bacteria use to protect themselves from antibiotics
Adopting a lying down position rather than being upright in the later stages of labour for first-time mothers who have had a low dose epidural leads to a higher chance of them delivering their baby without any medical intervention, a study has found.

Health - 10.11.2017
HPV jab means women only need three cervical screens in a lifetime
Women may only need three cervical screens in their lifetime if they have been given the human papillomavirus (HPV) vaccine, according to a new study by Queen Mary University of London (QMUL). The Cancer Research UK-funded team found that three screens at 30, 40 and 55 would offer the same benefit to vaccinated women as the 12 lifetime screens currently offered in England.

Chemistry - Health - 09.11.2017
Fatty molecule in human blood controls malaria parasites’ decision to leap to mosquitoes
Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team co-led by the University of Glasgow. The discovery, published online in Cell, answers a longstanding question about what controls this critical step in the life cycle of Plasmodium falciparum , the parasite responsible for about half a million malaria deaths worldwide each year.

Life Sciences - Health - 09.11.2017
New DNA antenatal screening for Down’s syndrome is a ’transformational advance’
Scientists at Queen Mary University of London (QMUL) have shown for the first time that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders, including Down's syndrome, in a way that is far more accurate, and safer and less stressful for mothers.

Health - 08.11.2017
Breast cancer study suggests review of treatment length
A new study published in the New England Journal of Medicine , funded by Cancer Research UK, has found that the risk of breast cancer recurring persists undiminished for at least 20 years after diagnosis, suggesting that hormonal treatments should continue for even longer to reduce the risk of late recurrence.

Life Sciences - Health - 08.11.2017
Tiny silicon probes provide high definition recording of brain activity
A team involving UCL scientists has developed a new device that could revolutionise our understanding of the brain by allowing researchers to map the activity of complex neural networks that control behaviour and decision making, in a way never before possible. The Neuropixels probes are described in a paper .