Human heart cells respond less to e-cig vapour than tobacco smoke

New research has showed substantial differences in the way human heart cells respond to e-cigarette smoke and conventional cigarette smoke. Researchers from the Medical Research Council Integrative Epidemiology Unit (MRC IEU) at the University of Bristol investigated how the same type of cells as those found in the arteries of the heart, known as human coronary artery endothelial cells (HCAEC), responded when they were exposed to both e-cigarette aerosol and conventional cigarette smoke. Their Professor Marcus Munafò , who was part of the study team, said: "The past few years have seen a rapid growth in the use of e-cigarettes, which deliver nicotine via inhaled aerosol. It's thought that e-cigarettes are unlikely to be as harmful as conventional cigarettes, but little data exists to show their relative harms, or the long term effects of e-cigarette use. Therefore, research into these biological effects is critical. Our study looked at the stress response in heart cells in response to cigarette smoke and e-cigarette aerosol." The researchers created cigarette smoke extract from a conventional cigarette and electronic cigarette aerosol extract from an e-cigarette aerosol. Both were passed through a culture of the cells.