Treatment to open blocked kidney arteries shows no real benefit to patients

Treating patients who suffer from narrowing of the main blood vessel to the kidney by inserting a metal stent provides little or no worthwhile clinical benefit, and given the risk of serious complications it should be used less, according to an international trial led by the University of Birmingham. In findings published in the New England Journal of Medicine (12th November), scientists report that in most patients revascularisation, the process of opening up blocked blood vessels, does not stabilise or improve kidney function or blood pressure control or reduce cardiovascular disease or mortality, more than medical therapy alone. Atherosclerotic renal artery stenosis is a disease of the arteries in which fatty plaques develop on the inside of the main arteries to the kidneys affecting blood flow and the ability of the kidneys to work properly. The Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) trial is the largest trial to date into treatment for this kidney condition. The seven year trial funded by the Medical Research Council, Kidney Research UK and Medtronic investigated whether combining revascularisation and medical therapy improved the condition compared to medical therapy alone. Keith Wheatley, who led the research at the University's Clinical Trials Unit (BCTU), says: "This study clearly illustrates that patients with renal artery stenosis remain at high risk. During the trial, a number of patients developed end-stage renal disease and needed dialysis or had a heart attack or stroke.