Research Associate - Bioorthogonal Site-selective Chemistry (Fixed Term)

Closing Date
WorkplaceCambridge, East of England, UK


Job Opportunities


Research Associate - Bioorthogonal Site-selective Chemistry (Fixed Term)

Fixed-term: The funds for this post are available for 1 year in the first instance.

Applications are invited for a post-doctoral research associate to join the group of Dr Bernardes at the Department of Chemistry, University of Cambridge to work on the ERC Starting Grant "TagIt". The role is to design and apply new methods that allow the re-design of the structure and function of proteins without sequence engineering, i.e. targeting naturally occurring amino acids. The method will be used to conjugate drugs to proteins that target specific biomarkers in the context cancer.

The successful candidate will perform reaction engineering in aqueous solution to apply in the context of site-selective protein modification. This will consist of reaction optimisation and synthesis of suitable reagents, test the conditions developed at the protein level, purify and characterise (mass spectrometry and biophysical measurements such as SPR and CD), and generation of a protein-drug conjugate.

The successful candidate will have (or be about to obtain) a PhD in chemical biology/synthetic chemistry. They will be highly motivated and able to work independently. Excellent organisational and interpersonal skills are required to ensure success in liaising with a large and diverse research team. Previous experience with bioconjugation chemistry and purification and characterisation of protein conjugates by advanced mass spectrometry is desirable.

Click the ’Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries relating to your application or the application process, please contact Dr Gonçalo Bernardes via email on gb453 [at] cam[.]ac[.]uk .

Please quote reference MA20348 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information


Department of Chemistry








14 August 2019

Closing date

18 September 2019
In your application, please refer to
and reference  JobID 171531.

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